| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 21 | 21 | 9 | 10 | 3.98 | .304 | 1.27 | 9.4 | 2.0 | 4.6 | 147.0 | 154 | 71 | 65 | 13 | 32 | 75 | 2 | 0 | 0 | 1 | 10 | 7 | 4 | 3.93 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 20 | 20 | 7 | 7 | 5.51 | .340 | 1.53 | 10.1 | 3.8 | 8.9 | 117.2 | 131 | 73 | 72 | 12 | 49 | 116 | 0 | 0 | 0 | 0 | 8 | 2 | 3 | 3.66 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 19 | 19 | 5 | 11 | 6.03 | .338 | 1.50 | 9.9 | 3.6 | 5.2 | 125.1 | 138 | 91 | 84 | 20 | 50 | 72 | 3 | 0 | 0 | 0 | 4 | 4 | 1 | 5.22 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 44 | 0 | 2 | 3 | 3.72 | .307 | 1.28 | 7.2 | 4.3 | 10.2 | 46.0 | 37 | 20 | 19 | 4 | 22 | 52 | 0 | 25 | 2 | 0 | 0 | 2 | 0 | 3.43 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 49 | 0 | 1 | 2 | 4.43 | .330 | 1.48 | 8.6 | 4.7 | 9.1 | 61.0 | 58 | 30 | 30 | 4 | 32 | 62 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.39 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 86 | 49 | 0 | 2 | 1 | 4.42 | .317 | 1.39 | 8.1 | 4.4 | 10.7 | 59.0 | 53 | 30 | 29 | 5 | 29 | 70 | 0 | 1 | 1 | 0 | 0 | 0 | 5 | 3.20 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 32 | 0 | 0 | 1 | 3.15 | .331 | 1.46 | 7.4 | 5.8 | 7.7 | 34.1 | 28 | 13 | 12 | 3 | 22 | 29 | 0 | 3 | 1 | 0 | 0 | 1 | 4 | 4.47 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 31 | 0 | 2 | 0 | 2.86 | .297 | 1.27 | 9.8 | 1.9 | 7.1 | 34.2 | 37 | 12 | 11 | 2 | 7 | 27 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.79 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 14 | 0 | 2 | 0 | 7.31 | .342 | 1.50 | 11.3 | 2.3 | 11.3 | 16.0 | 20 | 13 | 13 | 4 | 4 | 20 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.69 |