| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 29 | 29 | 9 | 11 | 4.99 | .322 | 1.41 | 10.1 | 2.6 | 8.9 | 182.0 | 205 | 107 | 101 | 29 | 52 | 179 | 1 | 0 | 0 | 0 | 13 | 2 | 0 | 3.99 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 28 | 28 | 13 | 10 | 4.70 | .338 | 1.48 | 9.2 | 4.1 | 4.4 | 168.2 | 172 | 88 | 88 | 18 | 77 | 83 | 0 | 0 | 0 | 0 | 13 | 9 | 2 | 4.94 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 66 | 0 | 8 | 6 | 3.47 | .300 | 1.29 | 7.1 | 4.5 | 9.3 | 70.0 | 55 | 27 | 27 | 4 | 35 | 72 | 0 | 27 | 4 | 0 | 0 | 0 | 2 | 3.19 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 90 | 0 | 10 | 4 | 3.11 | .291 | 1.21 | 7.7 | 3.2 | 8.5 | 107.0 | 92 | 41 | 37 | 12 | 38 | 101 | 0 | 5 | 4 | 0 | 0 | 2 | 0 | 3.69 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 70 | 0 | 2 | 5 | 3.78 | .290 | 1.20 | 7.5 | 3.4 | 9.9 | 83.1 | 69 | 37 | 35 | 13 | 31 | 91 | 0 | 1 | 2 | 0 | 0 | 2 | 3 | 4.04 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 53 | 0 | 2 | 0 | 3.15 | .257 | 1.02 | 7.3 | 1.9 | 6.8 | 65.2 | 53 | 29 | 23 | 7 | 14 | 49 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 3.58 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 46 | 0 | 2 | 1 | 3.64 | .326 | 1.44 | 9.2 | 3.8 | 6.5 | 54.1 | 55 | 28 | 22 | 8 | 23 | 39 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.81 |