| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 35 | 35 | 19 | 6 | 3.11 | .273 | 1.12 | 7.5 | 2.6 | 7.8 | 217.0 | 180 | 82 | 75 | 20 | 62 | 189 | 1 | 0 | 0 | 0 | 26 | 3 | 4 | 3.35 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 35 | 35 | 17 | 12 | 3.44 | .281 | 1.15 | 8.4 | 2.0 | 5.9 | 230.0 | 214 | 100 | 88 | 19 | 51 | 150 | 3 | 0 | 0 | 2 | 24 | 4 | 4 | 3.49 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 87 | 0 | 8 | 4 | 2.78 | .293 | 1.20 | 6.1 | 4.8 | 9.6 | 116.2 | 78 | 37 | 36 | 7 | 62 | 124 | 0 | 8 | 7 | 0 | 0 | 5 | 3 | 3.38 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 86 | 0 | 6 | 8 | 3.33 | .267 | 1.08 | 6.9 | 2.9 | 8.7 | 105.1 | 80 | 42 | 39 | 11 | 34 | 101 | 0 | 14 | 7 | 0 | 0 | 1 | 3 | 3.44 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 72 | 0 | 5 | 3 | 3.05 | .265 | 1.07 | 8.1 | 1.7 | 6.9 | 76.2 | 68 | 27 | 26 | 5 | 14 | 58 | 0 | 15 | 2 | 0 | 0 | 1 | 0 | 2.92 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 33 | 0 | 0 | 2 | 3.65 | .327 | 1.43 | 6.3 | 6.6 | 8.3 | 37.0 | 26 | 16 | 15 | 4 | 27 | 34 | 0 | 5 | 1 | 0 | 0 | 1 | 3 | 4.84 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 15 | 0 | 2 | 1 | 5.40 | .286 | 1.20 | 4.8 | 6.0 | 10.8 | 15.0 | 8 | 9 | 9 | 0 | 10 | 18 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 2.60 |
| RP | Eichhorn, M.Eichhorn, Mark # >> | 26 | 1986 | R | 48 | 38 | 0 | 2 | 3 | 5.19 | .337 | 1.49 | 9.3 | 4.2 | 6.7 | 86.2 | 89 | 55 | 50 | 13 | 40 | 64 | 0 | 1 | 0 | 0 | 0 | 3 | 2 | 4.98 |