| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 20 | 20 | 8 | 4 | 2.73 | .288 | 1.19 | 7.0 | 3.8 | 5.1 | 132.0 | 102 | 44 | 40 | 8 | 55 | 75 | 1 | 0 | 0 | 0 | 15 | 3 | 2 | 3.97 |
| SP | Mathewson, C.Mathewson, Christy † >> | 29 | 1909 | R | 85 | 21 | 20 | 14 | 2 | 2.88 | .261 | 1.03 | 7.5 | 1.8 | 4.1 | 146.2 | 121 | 47 | 47 | 9 | 30 | 66 | 3 | 0 | 0 | 1 | 14 | 4 | 1 | 3.60 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 83 | 20 | 20 | 9 | 7 | 3.40 | .277 | 1.15 | 9.0 | 1.4 | 9.0 | 132.1 | 132 | 52 | 50 | 14 | 20 | 132 | 1 | 0 | 0 | 0 | 14 | 0 | 3 | 2.83 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 20 | 20 | 8 | 6 | 4.55 | .320 | 1.41 | 8.4 | 4.3 | 7.4 | 116.2 | 108 | 59 | 59 | 15 | 56 | 96 | 1 | 0 | 0 | 0 | 8 | 1 | 4 | 4.50 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 94 | 56 | 0 | 5 | 4 | 2.03 | .252 | 1.01 | 5.5 | 3.6 | 7.8 | 80.0 | 49 | 19 | 18 | 5 | 32 | 69 | 0 | 10 | 4 | 0 | 0 | 0 | 0 | 3.29 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 18 | 0 | 3 | 2 | 5.30 | .333 | 1.50 | 9.0 | 5.0 | 8.0 | 18.2 | 18 | 11 | 11 | 3 | 10 | 16 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.06 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 62 | 2 | 0 | 0 | 0 | 0.00 | .091 | 0.30 | 0.0 | 3.0 | 6.0 | 3.1 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.67 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 20 | 0 | 3 | 1 | 4.21 | .288 | 1.21 | 7.5 | 3.4 | 6.5 | 47.0 | 39 | 22 | 22 | 4 | 18 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.81 |