| SP | Tiant, L.Tiant, Luis $ >> | 28 | 1968 | R | 97 | 30 | 30 | 9 | 18 | 4.12 | .297 | 1.24 | 7.9 | 3.2 | 8.3 | 214.1 | 189 | 102 | 98 | 28 | 76 | 197 | 9 | 0 | 0 | 0 | 15 | 7 | 4 | 4.02 |
| SP | Maddux, G.Maddux, Greg $ >> | 29 | 1995 | R | 89 | 30 | 30 | 6 | 18 | 5.86 | .320 | 1.38 | 9.7 | 2.7 | 5.5 | 184.1 | 199 | 123 | 120 | 24 | 55 | 112 | 4 | 0 | 0 | 1 | 10 | 6 | 4 | 4.47 |
| SP | Santana, J.Santana, Johan $ >> | 25 | 2004 | L | 86 | 29 | 29 | 12 | 9 | 4.39 | .298 | 1.24 | 8.1 | 3.1 | 7.8 | 186.2 | 168 | 96 | 91 | 22 | 64 | 161 | 1 | 0 | 0 | 1 | 14 | 6 | 5 | 3.94 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 29 | 29 | 9 | 15 | 6.45 | .347 | 1.59 | 11.1 | 3.3 | 6.4 | 189.2 | 233 | 145 | 136 | 34 | 69 | 135 | 1 | 0 | 0 | 0 | 7 | 0 | 4 | 5.01 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 95 | 52 | 0 | 3 | 6 | 3.23 | .281 | 1.15 | 6.3 | 4.1 | 7.8 | 53.0 | 37 | 20 | 19 | 6 | 24 | 46 | 0 | 31 | 4 | 0 | 0 | 1 | 0 | 4.15 |
| SU | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 40 | 0 | 3 | 1 | 3.40 | .293 | 1.22 | 6.6 | 4.4 | 4.8 | 45.0 | 33 | 18 | 17 | 8 | 22 | 24 | 0 | 5 | 6 | 0 | 0 | 1 | 0 | 5.78 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 73 | 0 | 3 | 2 | 3.27 | .297 | 1.25 | 9.0 | 2.3 | 9.5 | 82.2 | 82 | 32 | 30 | 12 | 21 | 87 | 0 | 3 | 3 | 0 | 0 | 2 | 3 | 3.62 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 49 | 0 | 1 | 3 | 3.84 | .304 | 1.31 | 7.0 | 4.9 | 8.1 | 63.1 | 49 | 28 | 27 | 9 | 34 | 57 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 4.67 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 35 | 0 | 4 | 1 | 2.33 | .261 | 1.06 | 6.4 | 3.3 | 9.5 | 38.2 | 27 | 10 | 10 | 5 | 14 | 40 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.71 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 28 | 0 | 7 | 1 | 4.54 | .308 | 1.32 | 8.5 | 3.4 | 6.8 | 107.0 | 101 | 54 | 54 | 11 | 40 | 81 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.00 |