| SP | Tiant, L.Tiant, Luis $ >> | 28 | 1968 | R | 97 | 36 | 36 | 19 | 12 | 3.52 | .292 | 1.20 | 7.4 | 3.4 | 7.7 | 240.1 | 198 | 98 | 94 | 16 | 91 | 204 | 5 | 0 | 0 | 2 | 25 | 8 | 3 | 3.40 |
| SP | Alexander, P.Alexander, Pete $ >> | 28 | 1915 | R | 88 | 34 | 34 | 10 | 14 | 4.10 | .305 | 1.31 | 8.8 | 3.0 | 4.7 | 228.1 | 223 | 111 | 104 | 17 | 75 | 118 | 4 | 0 | 0 | 1 | 17 | 3 | 3 | 3.96 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 33 | 33 | 12 | 15 | 5.42 | .340 | 1.53 | 9.6 | 4.1 | 8.6 | 196.0 | 210 | 123 | 118 | 42 | 89 | 188 | 1 | 0 | 0 | 1 | 11 | 4 | 5 | 5.29 |
| SP | Guidry, R.Guidry, Ron † >> | 28 | 1978 | L | 77 | 31 | 31 | 16 | 11 | 4.03 | .280 | 1.16 | 7.3 | 3.2 | 5.0 | 216.2 | 176 | 104 | 97 | 19 | 76 | 120 | 9 | 0 | 0 | 1 | 18 | 1 | 6 | 4.10 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 67 | 0 | 6 | 3 | 2.23 | .235 | 0.88 | 5.3 | 2.8 | 9.1 | 72.2 | 42 | 18 | 18 | 5 | 22 | 73 | 0 | 42 | 5 | 0 | 0 | 3 | 0 | 2.92 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 53 | 0 | 4 | 2 | 3.33 | .277 | 1.13 | 6.7 | 3.5 | 8.0 | 54.0 | 40 | 21 | 20 | 4 | 21 | 48 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 3.41 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 38 | 0 | 2 | 0 | 3.21 | .302 | 1.28 | 8.2 | 3.4 | 10.0 | 47.2 | 43 | 17 | 17 | 7 | 18 | 52 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.94 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 66 | 23 | 0 | 2 | 1 | 3.87 | .301 | 1.27 | 7.4 | 4.1 | 5.7 | 97.2 | 80 | 42 | 42 | 8 | 44 | 61 | 0 | 1 | 0 | 0 | 0 | 2 | 2 | 4.24 |