| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 31 | 31 | 13 | 10 | 3.78 | .279 | 1.14 | 7.7 | 2.6 | 8.9 | 212.0 | 181 | 91 | 89 | 27 | 61 | 210 | 1 | 0 | 0 | 1 | 22 | 4 | 3 | 3.59 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 90 | 30 | 30 | 13 | 5 | 4.19 | .302 | 1.26 | 8.4 | 3.0 | 9.9 | 210.2 | 196 | 100 | 98 | 33 | 70 | 231 | 4 | 0 | 0 | 0 | 13 | 7 | 4 | 3.94 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 29 | 29 | 11 | 12 | 5.09 | .307 | 1.31 | 9.7 | 2.1 | 4.8 | 207.0 | 223 | 124 | 117 | 36 | 49 | 111 | 7 | 0 | 0 | 0 | 8 | 3 | 1 | 4.94 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 29 | 29 | 11 | 11 | 5.03 | .320 | 1.38 | 9.1 | 3.4 | 7.3 | 196.2 | 199 | 112 | 110 | 29 | 73 | 160 | 4 | 0 | 0 | 2 | 12 | 6 | 12 | 4.50 |
| RP | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 80 | 0 | 5 | 6 | 2.80 | .245 | 0.94 | 6.1 | 2.4 | 8.2 | 106.0 | 72 | 36 | 33 | 12 | 28 | 96 | 0 | 9 | 5 | 0 | 0 | 3 | 1 | 3.54 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 62 | 0 | 8 | 2 | 3.13 | .273 | 1.10 | 6.6 | 3.3 | 8.9 | 72.0 | 53 | 28 | 25 | 9 | 26 | 71 | 0 | 10 | 3 | 0 | 0 | 2 | 5 | 3.82 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 40 | 0 | 9 | 1 | 1.86 | .220 | 0.83 | 6.0 | 1.5 | 8.4 | 48.1 | 32 | 10 | 10 | 3 | 8 | 45 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 2.50 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 28 | 0 | 3 | 2 | 2.57 | .236 | 0.93 | 5.5 | 2.9 | 11.6 | 28.0 | 17 | 8 | 8 | 5 | 9 | 36 | 0 | 5 | 1 | 0 | 0 | 0 | 1 | 3.71 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 15 | 0 | 4 | 0 | 3.78 | .296 | 1.26 | 6.8 | 5.1 | 8.4 | 16.2 | 12 | 7 | 7 | 1 | 9 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.63 |