| SP | deGrom, J.deGrom, Jacob † # >> | 33 | 2021 | R | 100 | 19 | 19 | 10 | 4 | 3.58 | .279 | 1.14 | 7.8 | 2.4 | 10.0 | 123.1 | 107 | 53 | 49 | 15 | 33 | 137 | 0 | 0 | 0 | 0 | 14 | 3 | 0 | 3.24 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 18 | 18 | 6 | 5 | 3.84 | .285 | 1.17 | 8.5 | 2.0 | 5.6 | 129.0 | 122 | 57 | 55 | 10 | 29 | 80 | 3 | 0 | 0 | 1 | 10 | 3 | 1 | 3.51 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 18 | 18 | 5 | 9 | 5.10 | .329 | 1.46 | 10.1 | 3.1 | 5.7 | 118.1 | 132 | 79 | 67 | 14 | 41 | 75 | 2 | 0 | 0 | 0 | 8 | 1 | 1 | 4.34 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 18 | 17 | 6 | 8 | 4.67 | .299 | 1.26 | 8.2 | 3.2 | 5.4 | 111.2 | 101 | 59 | 58 | 7 | 40 | 66 | 3 | 0 | 0 | 2 | 8 | 2 | 1 | 3.77 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 28 | 0 | 2 | 5 | 3.29 | .287 | 1.17 | 6.0 | 4.7 | 9.3 | 27.1 | 18 | 10 | 10 | 3 | 14 | 28 | 0 | 15 | 1 | 0 | 0 | 1 | 0 | 4.04 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 48 | 0 | 1 | 0 | 4.93 | .342 | 1.56 | 8.5 | 5.8 | 5.6 | 34.2 | 32 | 21 | 19 | 6 | 22 | 21 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 6.00 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 19 | 0 | 1 | 1 | 1.61 | .264 | 1.07 | 5.7 | 4.1 | 11.5 | 22.1 | 14 | 5 | 4 | 2 | 10 | 28 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 13 | 0 | 4 | 0 | 0.77 | .300 | 1.29 | 9.0 | 3.3 | 7.4 | 11.2 | 11 | 1 | 1 | 1 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.64 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 12 | 0 | 1 | 0 | 4.50 | .357 | 1.58 | 6.8 | 7.5 | 11.3 | 12.0 | 9 | 6 | 6 | 1 | 10 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.33 |