| SP | deGrom, J.deGrom, Jacob † $ >> | 33 | 2021 | R | 100 | 32 | 32 | 19 | 8 | 3.23 | .253 | 1.00 | 6.9 | 2.1 | 8.8 | 214.2 | 164 | 77 | 77 | 25 | 50 | 209 | 3 | 0 | 0 | 0 | 23 | 4 | 0 | 3.32 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 30 | 30 | 12 | 6 | 3.92 | .311 | 1.33 | 8.4 | 3.5 | 5.4 | 163.0 | 153 | 72 | 71 | 19 | 63 | 97 | 0 | 0 | 0 | 0 | 10 | 5 | 6 | 4.58 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 29 | 29 | 14 | 11 | 4.27 | .318 | 1.39 | 9.1 | 3.3 | 5.6 | 192.0 | 195 | 96 | 91 | 16 | 71 | 120 | 2 | 0 | 0 | 1 | 17 | 2 | 3 | 3.97 |
| SU | Doolittle, S.Doolittle, Sean $$ >> | 31 | 2018 | L | 98 | 55 | 0 | 2 | 2 | 4.19 | .267 | 1.10 | 6.3 | 3.7 | 10.5 | 66.2 | 46 | 32 | 31 | 13 | 27 | 77 | 0 | 4 | 8 | 0 | 0 | 0 | 0 | 4.45 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 92 | 59 | 0 | 2 | 4 | 2.58 | .249 | 0.98 | 5.9 | 2.9 | 9.6 | 59.1 | 39 | 18 | 17 | 8 | 19 | 63 | 0 | 36 | 2 | 0 | 0 | 1 | 0 | 3.64 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 38 | 0 | 1 | 4 | 4.33 | .289 | 1.19 | 8.0 | 2.8 | 9.5 | 35.1 | 31 | 17 | 17 | 6 | 11 | 37 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.14 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 65 | 76 | 0 | 4 | 5 | 5.17 | .310 | 1.35 | 9.5 | 2.8 | 7.7 | 55.2 | 58 | 32 | 32 | 8 | 17 | 47 | 0 | 1 | 4 | 0 | 0 | 0 | 3 | 4.11 |