| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 24 | 24 | 10 | 8 | 3.49 | .258 | 1.03 | 7.6 | 1.8 | 8.4 | 162.2 | 136 | 69 | 63 | 14 | 32 | 152 | 1 | 0 | 0 | 1 | 15 | 2 | 0 | 2.88 |
| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 23 | 23 | 9 | 7 | 3.45 | .281 | 1.17 | 8.4 | 2.1 | 8.4 | 172.0 | 160 | 75 | 66 | 19 | 41 | 161 | 3 | 0 | 0 | 1 | 15 | 1 | 2 | 3.30 |
| SP | Cueto, J.Cueto, Johnny † # >> | 28 | 2014 | R | 75 | 22 | 22 | 13 | 6 | 3.59 | .285 | 1.17 | 7.8 | 2.7 | 7.6 | 168.0 | 146 | 78 | 67 | 20 | 50 | 142 | 6 | 0 | 0 | 1 | 14 | 5 | 1 | 3.84 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 23 | 22 | 5 | 12 | 5.56 | .344 | 1.57 | 10.0 | 4.3 | 5.1 | 150.2 | 166 | 104 | 93 | 26 | 71 | 85 | 5 | 0 | 0 | 1 | 5 | 0 | 0 | 5.54 |
| RP | Adams, M.Adams, Mike # >> | 31 | 2009 | R | 99 | 58 | 0 | 1 | 7 | 5.87 | .330 | 1.46 | 8.2 | 5.0 | 8.2 | 69.0 | 63 | 53 | 45 | 12 | 38 | 63 | 0 | 6 | 5 | 0 | 0 | 1 | 0 | 5.13 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 51 | 0 | 1 | 3 | 3.96 | .343 | 1.57 | 8.7 | 5.5 | 8.7 | 61.1 | 59 | 27 | 27 | 7 | 37 | 59 | 0 | 6 | 2 | 0 | 0 | 0 | 1 | 4.38 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 39 | 0 | 4 | 1 | 2.01 | .278 | 1.16 | 5.7 | 4.8 | 9.0 | 49.1 | 31 | 11 | 11 | 2 | 26 | 49 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 3.12 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 16 | 0 | 0 | 3 | 9.42 | .442 | 2.30 | 14.8 | 6.4 | 13.5 | 14.1 | 23 | 15 | 15 | 5 | 10 | 21 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 7.00 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 6 | 0 | 0 | 2 | 2.08 | .297 | 1.27 | 9.0 | 3.4 | 4.5 | 8.2 | 8 | 2 | 2 | 1 | 3 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.75 |