| SP | Richard, J.Richard, J.R. † >> | 30 | 1980 | R | 90 | 24 | 24 | 12 | 5 | 2.69 | .280 | 1.15 | 6.7 | 3.7 | 7.3 | 150.2 | 112 | 45 | 45 | 7 | 62 | 121 | 0 | 0 | 0 | 0 | 17 | 2 | 3 | 3.27 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 23 | 23 | 5 | 11 | 4.08 | .300 | 1.27 | 8.7 | 2.7 | 7.2 | 139.0 | 134 | 63 | 63 | 18 | 42 | 111 | 1 | 0 | 0 | 0 | 14 | 3 | 2 | 4.06 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 23 | 23 | 11 | 7 | 2.93 | .270 | 1.09 | 7.4 | 2.5 | 6.5 | 156.2 | 128 | 58 | 51 | 13 | 43 | 113 | 1 | 0 | 0 | 1 | 17 | 3 | 2 | 3.52 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 58 | 20 | 18 | 6 | 5 | 3.48 | .297 | 1.24 | 8.3 | 2.9 | 5.0 | 124.0 | 114 | 55 | 48 | 13 | 40 | 69 | 3 | 0 | 0 | 1 | 13 | 3 | 3 | 4.29 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 70 | 0 | 1 | 1 | 2.32 | .276 | 1.12 | 6.2 | 4.0 | 7.2 | 54.1 | 37 | 15 | 14 | 3 | 24 | 43 | 0 | 1 | 4 | 0 | 0 | 1 | 6 | 3.52 |
| RP | Fingers, R.Fingers, Rollie >> | 35 | 1981 | R | 53 | 46 | 0 | 5 | 2 | 3.30 | .245 | 0.95 | 7.0 | 1.6 | 6.7 | 46.1 | 36 | 17 | 17 | 4 | 8 | 34 | 0 | 0 | 3 | 0 | 0 | 1 | 1 | 3.24 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 64 | 0 | 0 | 3 | 3.83 | .267 | 1.07 | 4.8 | 5.0 | 8.8 | 49.1 | 26 | 21 | 21 | 4 | 27 | 48 | 0 | 1 | 2 | 0 | 0 | 1 | 5 | 3.82 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 49 | 32 | 0 | 1 | 1 | 5.54 | .310 | 1.31 | 9.0 | 2.8 | 8.7 | 26.0 | 26 | 16 | 16 | 6 | 8 | 25 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.12 |
| CL | Holland, G.Holland, Greg † >> | 27 | 2013 | R | 71 | 51 | 0 | 6 | 7 | 2.04 | .271 | 1.08 | 6.9 | 2.8 | 9.5 | 57.1 | 44 | 16 | 13 | 3 | 18 | 60 | 0 | 29 | 4 | 0 | 0 | 2 | 2 | 2.63 |