| SP | Snell, B.Snell, Blake † >> | 25 | 2018 | L | 81 | 25 | 25 | 15 | 4 | 2.45 | .255 | 0.99 | 6.2 | 2.7 | 8.4 | 161.1 | 111 | 48 | 44 | 13 | 49 | 151 | 1 | 0 | 0 | 1 | 19 | 6 | 3 | 3.20 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 26 | 26 | 12 | 9 | 3.48 | .273 | 1.11 | 7.7 | 2.3 | 7.5 | 186.1 | 159 | 78 | 72 | 17 | 48 | 154 | 3 | 0 | 0 | 1 | 18 | 3 | 2 | 3.35 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 25 | 25 | 10 | 6 | 3.65 | .296 | 1.24 | 7.7 | 3.5 | 8.7 | 155.1 | 132 | 65 | 63 | 17 | 61 | 149 | 0 | 0 | 0 | 0 | 16 | 3 | 3 | 3.74 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 23 | 23 | 8 | 10 | 4.92 | .305 | 1.29 | 8.7 | 3.0 | 8.3 | 133.2 | 128 | 77 | 73 | 19 | 45 | 122 | 2 | 0 | 0 | 1 | 10 | 3 | 3 | 4.11 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 73 | 0 | 3 | 1 | 3.09 | .273 | 1.13 | 6.5 | 3.7 | 8.6 | 64.0 | 46 | 23 | 22 | 10 | 26 | 61 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 4.34 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 33 | 0 | 2 | 2 | 2.70 | .256 | 1.03 | 6.3 | 3.0 | 8.7 | 30.0 | 21 | 9 | 9 | 4 | 10 | 29 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.80 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 30 | 0 | 3 | 0 | 4.18 | .336 | 1.52 | 7.4 | 6.7 | 7.0 | 23.2 | 19 | 16 | 11 | 4 | 17 | 18 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 5.91 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 64 | 0 | 3 | 2 | 1.46 | .252 | 0.99 | 6.4 | 2.6 | 7.7 | 55.1 | 39 | 10 | 9 | 4 | 16 | 47 | 0 | 1 | 2 | 0 | 0 | 1 | 5 | 3.16 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 47 | 0 | 4 | 0 | 4.50 | .322 | 1.40 | 8.8 | 3.8 | 8.3 | 40.0 | 39 | 22 | 20 | 4 | 17 | 37 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.80 |
| CL | Holland, G.Holland, Greg † >> | 27 | 2013 | R | 72 | 57 | 0 | 3 | 2 | 3.00 | .274 | 1.12 | 6.0 | 4.1 | 8.3 | 60.0 | 40 | 20 | 20 | 9 | 27 | 55 | 0 | 35 | 4 | 0 | 0 | 1 | 2 | 4.52 |