| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 25 | 25 | 10 | 9 | 3.59 | .272 | 1.10 | 7.2 | 2.7 | 9.2 | 163.0 | 131 | 67 | 65 | 12 | 49 | 167 | 0 | 0 | 0 | 0 | 16 | 3 | 0 | 2.87 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 25 | 25 | 7 | 11 | 5.21 | .322 | 1.37 | 9.6 | 2.8 | 9.7 | 160.2 | 171 | 94 | 93 | 28 | 49 | 172 | 0 | 0 | 0 | 0 | 9 | 9 | 4 | 4.21 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 24 | 24 | 8 | 14 | 5.37 | .333 | 1.49 | 9.6 | 3.8 | 6.6 | 159.1 | 169 | 105 | 95 | 17 | 68 | 116 | 2 | 0 | 0 | 0 | 9 | 2 | 11 | 4.25 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 25 | 24 | 9 | 14 | 5.61 | .351 | 1.60 | 9.8 | 4.6 | 5.3 | 142.2 | 155 | 95 | 89 | 20 | 73 | 84 | 0 | 0 | 0 | 0 | 10 | 3 | 2 | 5.25 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 66 | 0 | 4 | 2 | 2.52 | .269 | 1.07 | 6.2 | 3.5 | 7.4 | 78.2 | 54 | 27 | 22 | 7 | 30 | 64 | 0 | 11 | 1 | 0 | 0 | 3 | 3 | 3.79 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 41 | 0 | 1 | 2 | 3.23 | .291 | 1.15 | 7.2 | 3.2 | 11.3 | 39.0 | 31 | 15 | 14 | 3 | 14 | 49 | 0 | 6 | 1 | 0 | 0 | 3 | 0 | 2.79 |
| RP | Gregerson, L.Gregerson, Luke # >> | 26 | 2010 | R | 73 | 28 | 0 | 1 | 2 | 8.31 | .333 | 1.50 | 8.0 | 5.5 | 8.0 | 26.0 | 23 | 26 | 24 | 8 | 16 | 23 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 7.08 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 28 | 0 | 1 | 1 | 4.55 | .336 | 1.52 | 9.3 | 4.7 | 8.1 | 29.2 | 30 | 16 | 15 | 2 | 15 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 3.66 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 6 | 0 | 0 | 0 | 13.50 | .529 | 3.38 | 18.0 | 14.4 | 3.6 | 5.1 | 10 | 8 | 8 | 1 | 8 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 9.60 |