| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 24 | 24 | 8 | 13 | 4.33 | .318 | 1.37 | 9.7 | 2.6 | 7.5 | 174.2 | 188 | 103 | 84 | 22 | 51 | 145 | 6 | 0 | 0 | 0 | 12 | 5 | 2 | 3.94 |
| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 97 | 23 | 23 | 9 | 10 | 2.67 | .283 | 1.17 | 6.4 | 4.1 | 8.1 | 185.1 | 132 | 66 | 55 | 15 | 84 | 167 | 8 | 0 | 0 | 1 | 17 | 3 | 3 | 3.66 |
| SP | Scherzer, M.Scherzer, Max † # >> | 33 | 2017 | R | 95 | 23 | 23 | 15 | 4 | 2.71 | .260 | 1.03 | 6.9 | 2.4 | 9.2 | 172.2 | 132 | 53 | 52 | 13 | 46 | 175 | 4 | 0 | 0 | 0 | 18 | 4 | 5 | 2.82 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 91 | 23 | 23 | 8 | 13 | 5.99 | .329 | 1.45 | 10.4 | 2.7 | 8.7 | 139.2 | 160 | 103 | 93 | 26 | 42 | 134 | 1 | 0 | 0 | 0 | 10 | 3 | 1 | 4.47 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 24 | 23 | 4 | 10 | 5.48 | .351 | 1.61 | 10.8 | 3.7 | 5.0 | 118.1 | 142 | 83 | 72 | 16 | 48 | 65 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 4.93 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 54 | 0 | 0 | 2 | 4.71 | .309 | 1.31 | 8.2 | 3.6 | 8.9 | 65.0 | 59 | 34 | 34 | 6 | 26 | 64 | 0 | 7 | 4 | 0 | 0 | 2 | 4 | 3.52 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 79 | 43 | 0 | 2 | 3 | 4.13 | .323 | 1.36 | 7.1 | 5.2 | 9.0 | 52.1 | 41 | 24 | 24 | 7 | 30 | 52 | 0 | 4 | 6 | 0 | 0 | 4 | 4 | 4.71 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 37 | 0 | 1 | 1 | 4.20 | .348 | 1.57 | 7.4 | 7.0 | 11.0 | 40.2 | 33 | 20 | 19 | 5 | 31 | 49 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 4.58 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 30 | 0 | 3 | 5 | 4.34 | .325 | 1.39 | 9.0 | 3.6 | 5.8 | 37.1 | 37 | 22 | 18 | 8 | 15 | 24 | 0 | 3 | 0 | 0 | 0 | 2 | 2 | 5.89 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 17 | 0 | 1 | 0 | 1.33 | .265 | 1.03 | 6.8 | 2.7 | 5.4 | 20.1 | 15 | 6 | 3 | 2 | 6 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.15 |