| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 24 | 24 | 10 | 8 | 3.95 | .274 | 1.11 | 8.1 | 1.9 | 5.1 | 161.2 | 145 | 71 | 71 | 10 | 34 | 92 | 6 | 0 | 0 | 0 | 14 | 4 | 2 | 3.37 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 23 | 23 | 11 | 8 | 3.06 | .261 | 1.04 | 7.3 | 2.1 | 8.2 | 161.2 | 131 | 55 | 55 | 17 | 37 | 147 | 4 | 0 | 0 | 2 | 18 | 3 | 1 | 3.29 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 23 | 23 | 8 | 7 | 4.40 | .286 | 1.20 | 9.2 | 1.6 | 4.3 | 159.2 | 162 | 78 | 78 | 15 | 29 | 76 | 5 | 0 | 0 | 0 | 13 | 1 | 2 | 3.84 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 22 | 22 | 8 | 7 | 3.93 | .305 | 1.29 | 8.6 | 3.0 | 7.6 | 149.0 | 143 | 68 | 65 | 13 | 49 | 125 | 3 | 0 | 0 | 0 | 14 | 4 | 5 | 3.52 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 84 | 42 | 0 | 5 | 5 | 3.83 | .264 | 1.05 | 8.0 | 1.6 | 7.2 | 44.2 | 39 | 19 | 19 | 6 | 8 | 35 | 0 | 24 | 5 | 0 | 0 | 1 | 0 | 3.80 |
| SU | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 35 | 0 | 1 | 2 | 2.25 | .245 | 0.97 | 4.3 | 4.5 | 7.8 | 36.0 | 17 | 9 | 9 | 3 | 18 | 31 | 0 | 7 | 3 | 0 | 0 | 0 | 0 | 3.86 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 49 | 0 | 8 | 1 | 3.40 | .263 | 1.03 | 6.3 | 3.1 | 5.6 | 47.2 | 33 | 18 | 18 | 6 | 16 | 29 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 4.57 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 19 | 0 | 0 | 0 | 0.84 | .229 | 0.89 | 4.7 | 3.4 | 5.1 | 21.1 | 11 | 4 | 2 | 1 | 8 | 12 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.62 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 8 | 0 | 1 | 0 | 4.15 | .333 | 1.50 | 9.0 | 5.6 | 9.0 | 8.2 | 8 | 6 | 4 | 1 | 5 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.50 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 12 | 0 | 2 | 0 | 2.13 | .240 | 0.95 | 6.8 | 2.3 | 6.8 | 12.2 | 9 | 3 | 3 | 3 | 3 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.50 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 10 | 0 | 4 | 3 | 4.29 | .315 | 1.36 | 9.2 | 3.0 | 5.1 | 42.0 | 43 | 20 | 20 | 1 | 14 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.24 |