| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 26 | 26 | 12 | 6 | 4.46 | .319 | 1.38 | 10.3 | 2.2 | 9.0 | 167.1 | 191 | 85 | 83 | 25 | 40 | 167 | 0 | 0 | 0 | 0 | 14 | 4 | 2 | 3.74 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 26 | 25 | 12 | 7 | 4.88 | .305 | 1.28 | 9.1 | 2.5 | 10.4 | 153.0 | 154 | 85 | 83 | 26 | 42 | 176 | 0 | 0 | 0 | 0 | 13 | 5 | 2 | 3.83 |
| SP | Pepiot, R.Pepiot, Ryan # >> | 27 | 2025 | R | 80 | 25 | 25 | 12 | 3 | 4.58 | .335 | 1.46 | 9.5 | 3.7 | 10.0 | 135.2 | 142 | 71 | 69 | 14 | 56 | 150 | 0 | 0 | 0 | 0 | 10 | 7 | 1 | 3.53 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 84 | 69 | 0 | 7 | 1 | 4.03 | .327 | 1.43 | 10.7 | 2.2 | 9.7 | 89.1 | 106 | 43 | 40 | 12 | 22 | 96 | 0 | 0 | 4 | 0 | 0 | 2 | 0 | 3.40 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 62 | 0 | 4 | 1 | 2.68 | .282 | 1.14 | 8.1 | 2.2 | 9.9 | 77.1 | 69 | 25 | 23 | 7 | 19 | 85 | 0 | 1 | 0 | 0 | 0 | 3 | 1 | 2.83 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 68 | 62 | 0 | 4 | 2 | 2.15 | .257 | 0.96 | 7.3 | 1.3 | 6.4 | 75.1 | 61 | 21 | 18 | 5 | 11 | 53 | 0 | 0 | 3 | 0 | 0 | 6 | 0 | 3.13 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 66 | 16 | 2 | 0 | 7 | 11.57 | .440 | 2.25 | 14.8 | 5.5 | 10.3 | 28.0 | 46 | 36 | 36 | 6 | 17 | 32 | 0 | 1 | 3 | 0 | 0 | 3 | 0 | 5.64 |
| SU | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 90 | 66 | 0 | 2 | 2 | 4.19 | .315 | 1.36 | 8.6 | 3.8 | 9.4 | 62.1 | 59 | 32 | 29 | 6 | 26 | 65 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 3.47 |
| CL | Hader, J.Hader, Josh † >> | 31 | 2025 | L | 100 | 62 | 0 | 5 | 4 | 2.57 | .265 | 1.05 | 6.5 | 3.0 | 12.3 | 66.2 | 48 | 23 | 19 | 4 | 22 | 90 | 0 | 31 | 6 | 0 | 0 | 2 | 2 | 2.15 |