| SP | Schilling, C.Schilling, Curt # >> | 36 | 2002 | R | 93 | 31 | 31 | 13 | 9 | 4.40 | .310 | 1.32 | 9.7 | 2.2 | 9.1 | 221.0 | 238 | 109 | 108 | 26 | 53 | 224 | 2 | 0 | 0 | 1 | 17 | 7 | 3 | 3.32 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 24 | 2005 | R | 70 | 30 | 30 | 9 | 10 | 4.30 | .315 | 1.33 | 8.8 | 3.3 | 6.1 | 190.1 | 185 | 94 | 91 | 23 | 69 | 128 | 0 | 0 | 0 | 0 | 16 | 8 | 2 | 4.44 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 65 | 29 | 29 | 9 | 13 | 5.98 | .350 | 1.60 | 10.8 | 3.5 | 5.4 | 188.0 | 226 | 126 | 125 | 36 | 74 | 113 | 1 | 0 | 0 | 0 | 12 | 4 | 2 | 5.53 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 48 | 29 | 29 | 11 | 13 | 5.55 | .349 | 1.58 | 10.7 | 3.5 | 6.5 | 193.0 | 230 | 121 | 119 | 29 | 75 | 139 | 4 | 0 | 0 | 2 | 13 | 5 | 1 | 4.76 |
| SP | Patterson, J.Patterson, John >> | 27 | 2005 | R | 33 | 29 | 29 | 6 | 15 | 6.01 | .348 | 1.57 | 10.3 | 3.9 | 6.0 | 167.2 | 191 | 115 | 112 | 23 | 73 | 112 | 0 | 0 | 0 | 0 | 11 | 4 | 8 | 4.83 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 68 | 82 | 0 | 6 | 4 | 2.97 | .292 | 1.24 | 6.9 | 4.3 | 9.5 | 97.0 | 74 | 32 | 32 | 8 | 46 | 102 | 0 | 16 | 2 | 0 | 0 | 0 | 6 | 3.39 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 47 | 54 | 0 | 1 | 0 | 3.94 | .336 | 1.52 | 8.5 | 5.2 | 7.3 | 59.1 | 56 | 27 | 26 | 6 | 34 | 48 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 4.42 |
| RP | Remlinger, M.Remlinger, Mike >> | 36 | 2002 | L | 33 | 40 | 0 | 5 | 1 | 5.02 | .338 | 1.47 | 8.0 | 5.2 | 7.7 | 43.0 | 38 | 24 | 24 | 8 | 25 | 37 | 0 | 4 | 1 | 0 | 0 | 3 | 0 | 5.65 |
| RP | Seanez, R.Seanez, Rudy >> | 37 | 2005 | R | 20 | 36 | 0 | 4 | 1 | 4.29 | .304 | 1.29 | 8.8 | 2.8 | 9.6 | 42.0 | 41 | 20 | 20 | 7 | 13 | 45 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 4.02 |
| SP | Colon, B.Colon, Bartolo >> | 32 | 2005 | R | 22 | 21 | 0 | 1 | 3 | 6.83 | .356 | 1.62 | 11.5 | 3.1 | 6.8 | 29.0 | 37 | 23 | 22 | 6 | 10 | 22 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 5.31 |