| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 33 | 33 | 10 | 10 | 3.59 | .303 | 1.28 | 7.8 | 3.7 | 9.3 | 203.1 | 176 | 87 | 81 | 18 | 84 | 209 | 1 | 0 | 0 | 1 | 20 | 5 | 6 | 3.41 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 24 | 2005 | R | 71 | 32 | 32 | 9 | 15 | 5.02 | .322 | 1.41 | 9.1 | 3.5 | 7.3 | 186.1 | 189 | 105 | 104 | 30 | 73 | 151 | 1 | 0 | 0 | 0 | 13 | 4 | 4 | 4.72 |
| SP | Prior, M.Prior, Mark # >> | 23 | 2003 | R | 68 | 32 | 32 | 13 | 11 | 4.60 | .335 | 1.46 | 9.8 | 3.3 | 9.1 | 207.1 | 226 | 108 | 106 | 25 | 77 | 209 | 2 | 0 | 0 | 1 | 15 | 11 | 6 | 3.83 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 54 | 31 | 31 | 9 | 10 | 6.15 | .354 | 1.62 | 11.7 | 2.8 | 6.7 | 171.1 | 223 | 123 | 117 | 29 | 54 | 128 | 0 | 0 | 0 | 0 | 11 | 5 | 11 | 4.74 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 94 | 82 | 0 | 2 | 5 | 3.90 | .289 | 1.19 | 8.5 | 2.2 | 9.2 | 122.1 | 115 | 53 | 53 | 14 | 30 | 125 | 0 | 5 | 5 | 0 | 0 | 4 | 2 | 3.28 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 72 | 0 | 6 | 5 | 3.95 | .299 | 1.26 | 7.3 | 4.1 | 8.0 | 79.2 | 64 | 38 | 35 | 10 | 36 | 70 | 0 | 11 | 3 | 0 | 0 | 2 | 0 | 4.32 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 39 | 50 | 0 | 2 | 3 | 4.15 | .292 | 1.19 | 8.0 | 2.9 | 8.0 | 60.2 | 53 | 28 | 28 | 7 | 19 | 53 | 0 | 3 | 1 | 0 | 0 | 3 | 1 | 3.85 |
| SP | Miller, W.Miller, Wade >> | 25 | 2001 | R | 28 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 52 | 1 | 0 | 0 | 1 | 10.80 | .375 | 1.20 | 9.0 | 9.0 | 9.0 | 1.2 | 1 | 2 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 20.00 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 39 | 33 | 0 | 2 | 5 | 5.59 | .362 | 1.63 | 10.4 | 4.3 | 7.4 | 56.1 | 65 | 37 | 35 | 12 | 27 | 46 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | 5.80 |