| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 99 | 35 | 35 | 16 | 10 | 4.01 | .307 | 1.32 | 8.7 | 3.2 | 9.0 | 213.1 | 206 | 105 | 95 | 27 | 75 | 214 | 5 | 0 | 0 | 1 | 23 | 3 | 3 | 3.74 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 87 | 33 | 33 | 9 | 11 | 4.50 | .325 | 1.42 | 9.8 | 2.9 | 9.6 | 194.0 | 212 | 103 | 97 | 26 | 63 | 207 | 0 | 0 | 0 | 0 | 16 | 5 | 5 | 3.66 |
| SP | Bedard, E.Bedard, Erik # >> | 28 | 2007 | L | 81 | 31 | 31 | 10 | 10 | 5.53 | .347 | 1.57 | 10.6 | 3.5 | 8.9 | 171.0 | 202 | 107 | 105 | 26 | 67 | 170 | 1 | 0 | 0 | 0 | 14 | 4 | 3 | 4.23 |
| RP | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 68 | 0 | 6 | 8 | 4.54 | .304 | 1.28 | 9.1 | 2.5 | 7.8 | 73.1 | 74 | 46 | 37 | 12 | 20 | 63 | 0 | 29 | 8 | 0 | 0 | 2 | 0 | 4.32 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 67 | 0 | 6 | 0 | 4.55 | .271 | 1.09 | 7.5 | 2.4 | 7.3 | 65.1 | 54 | 33 | 33 | 11 | 17 | 53 | 0 | 5 | 1 | 0 | 0 | 2 | 1 | 4.45 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 38 | 0 | 3 | 3 | 2.87 | .288 | 1.13 | 7.1 | 3.1 | 5.7 | 47.0 | 37 | 15 | 15 | 5 | 16 | 30 | 0 | 1 | 1 | 0 | 0 | 4 | 0 | 4.38 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 68 | 48 | 0 | 2 | 0 | 3.86 | .317 | 1.37 | 9.8 | 2.7 | 8.6 | 46.2 | 50 | 23 | 20 | 7 | 14 | 44 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.04 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 65 | 0 | 6 | 5 | 3.20 | .262 | 1.00 | 6.3 | 2.7 | 10.1 | 76.0 | 53 | 27 | 27 | 9 | 23 | 85 | 0 | 5 | 6 | 0 | 0 | 5 | 3 | 3.41 |
| CL | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 84 | 76 | 0 | 2 | 5 | 3.73 | .295 | 1.21 | 6.2 | 4.8 | 9.7 | 89.1 | 61 | 39 | 37 | 12 | 47 | 96 | 0 | 5 | 3 | 0 | 0 | 4 | 5 | 4.31 |
| SP | Greinke, Z.Greinke, Zack # >> | 26 | 2009 | R | 77 | 32 | 1 | 7 | 3 | 4.89 | .300 | 1.23 | 8.5 | 2.6 | 8.5 | 134.1 | 127 | 76 | 73 | 21 | 38 | 126 | 0 | 1 | 0 | 0 | 0 | 8 | 4 | 4.19 |