| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 100 | 31 | 31 | 9 | 12 | 4.31 | .321 | 1.38 | 8.9 | 3.6 | 9.7 | 190.0 | 188 | 98 | 91 | 23 | 75 | 205 | 0 | 0 | 0 | 0 | 17 | 7 | 2 | 3.71 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 88 | 31 | 31 | 11 | 8 | 4.61 | .330 | 1.44 | 9.1 | 3.8 | 9.4 | 181.2 | 184 | 99 | 93 | 28 | 77 | 190 | 1 | 0 | 0 | 0 | 15 | 8 | 3 | 4.32 |
| SP | Greinke, Z.Greinke, Zack # >> | 26 | 2009 | R | 76 | 29 | 29 | 8 | 14 | 5.73 | .340 | 1.49 | 10.1 | 3.4 | 8.9 | 163.1 | 183 | 111 | 104 | 20 | 61 | 162 | 4 | 0 | 0 | 1 | 12 | 8 | 1 | 3.88 |
| SP | Prior, M.Prior, Mark # >> | 23 | 2003 | R | 68 | 30 | 29 | 14 | 10 | 5.94 | .360 | 1.67 | 11.5 | 3.5 | 9.1 | 153.0 | 195 | 112 | 101 | 41 | 60 | 155 | 3 | 0 | 0 | 2 | 11 | 3 | 9 | 5.69 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 84 | 74 | 0 | 4 | 2 | 4.01 | .295 | 1.19 | 6.0 | 4.7 | 10.2 | 76.1 | 51 | 38 | 34 | 14 | 40 | 86 | 0 | 0 | 1 | 0 | 0 | 5 | 1 | 4.91 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 55 | 0 | 3 | 2 | 3.44 | .301 | 1.27 | 6.1 | 5.4 | 10.6 | 55.0 | 37 | 22 | 21 | 3 | 33 | 65 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 3.20 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 78 | 41 | 0 | 4 | 2 | 2.59 | .286 | 1.18 | 6.8 | 4.0 | 13.0 | 41.2 | 31 | 14 | 12 | 4 | 18 | 59 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 2.78 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 88 | 49 | 0 | 3 | 3 | 3.44 | .256 | 1.03 | 5.9 | 3.5 | 9.5 | 52.1 | 34 | 22 | 20 | 9 | 20 | 55 | 0 | 8 | 6 | 0 | 0 | 0 | 1 | 4.29 |
| CL | Rivera, M.Rivera, Mariano † $ >> | 39 | 2008 | R | 97 | 57 | 0 | 4 | 6 | 3.05 | .309 | 1.29 | 7.9 | 3.7 | 8.4 | 56.0 | 49 | 20 | 19 | 5 | 23 | 52 | 0 | 35 | 2 | 0 | 0 | 3 | 0 | 3.70 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 52 | 85 | 0 | 3 | 2 | 4.66 | .291 | 1.20 | 7.6 | 3.2 | 7.7 | 56.0 | 47 | 30 | 29 | 13 | 20 | 48 | 0 | 1 | 3 | 0 | 0 | 2 | 0 | 5.48 |
| SP | Maddux, G.Maddux, Greg # >> | 34 | 2000 | R | 57 | 30 | 0 | 2 | 5 | 6.14 | .354 | 1.59 | 11.6 | 2.8 | 7.0 | 102.2 | 131 | 75 | 70 | 15 | 32 | 79 | 0 | 0 | 2 | 0 | 0 | 6 | 2 | 4.48 |