| SP | Schilling, C.Schilling, Curt † >> | 36 | 2002 | R | 93 | 34 | 34 | 15 | 12 | 4.17 | .303 | 1.27 | 9.1 | 2.3 | 9.9 | 224.2 | 227 | 111 | 104 | 25 | 58 | 246 | 4 | 0 | 0 | 2 | 18 | 8 | 6 | 3.14 |
| SP | Perez, O.Perez, Oliver $$ >> | 23 | 2004 | L | 76 | 32 | 32 | 12 | 6 | 4.15 | .325 | 1.41 | 8.5 | 4.2 | 9.3 | 208.1 | 196 | 99 | 96 | 28 | 97 | 214 | 0 | 0 | 0 | 0 | 16 | 8 | 4 | 4.21 |
| SP | Mussina, M.Mussina, Mike # >> | 33 | 2001 | R | 67 | 32 | 32 | 8 | 12 | 5.98 | .343 | 1.52 | 10.6 | 3.1 | 8.4 | 194.0 | 228 | 131 | 129 | 41 | 67 | 180 | 1 | 0 | 0 | 0 | 9 | 9 | 4 | 5.07 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 31 | 31 | 13 | 8 | 6.38 | .354 | 1.61 | 10.9 | 3.6 | 7.3 | 168.0 | 204 | 121 | 119 | 37 | 67 | 136 | 0 | 0 | 0 | 0 | 11 | 5 | 5 | 5.53 |
| RP | Dotel, O.Dotel, Octavio # >> | 29 | 2002 | R | 89 | 89 | 0 | 4 | 2 | 4.52 | .297 | 1.23 | 7.4 | 3.8 | 8.7 | 91.2 | 75 | 49 | 46 | 11 | 38 | 88 | 0 | 1 | 4 | 0 | 0 | 3 | 0 | 3.99 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 16 | 0 | 1 | 0 | 5.56 | .333 | 1.41 | 10.6 | 2.5 | 13.9 | 11.1 | 13 | 7 | 7 | 2 | 3 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.36 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 20 | 0 | 4 | 0 | 2.95 | .247 | 0.93 | 6.5 | 2.0 | 12.0 | 18.1 | 13 | 7 | 6 | 4 | 4 | 24 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.06 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 69 | 19 | 0 | 2 | 1 | 1.45 | .282 | 1.18 | 7.0 | 4.0 | 11.5 | 18.2 | 14 | 6 | 3 | 1 | 8 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.50 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 88 | 0 | 5 | 0 | 3.68 | .268 | 1.08 | 7.0 | 2.8 | 8.0 | 71.0 | 55 | 31 | 29 | 13 | 22 | 63 | 0 | 1 | 1 | 0 | 0 | 1 | 5 | 4.58 |
| CL | Nathan, J.Nathan, Joe † >> | 32 | 2006 | R | 98 | 60 | 0 | 3 | 7 | 4.69 | .375 | 1.74 | 11.6 | 4.3 | 10.3 | 55.2 | 71 | 30 | 29 | 4 | 26 | 63 | 0 | 37 | 8 | 0 | 0 | 3 | 4 | 3.24 |
| SU | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 50 | 0 | 4 | 4 | 4.78 | .304 | 1.31 | 9.7 | 2.3 | 8.8 | 52.2 | 56 | 29 | 28 | 11 | 13 | 51 | 0 | 5 | 10 | 0 | 0 | 0 | 0 | 4.54 |