| SP | Woodruff, B.Woodruff, Brandon >> | 28 | 2021 | R | 95 | 9 | 9 | 4 | 1 | 3.21 | .294 | 1.20 | 8.0 | 2.7 | 11.3 | 56.0 | 50 | 20 | 20 | 9 | 17 | 70 | 0 | 0 | 0 | 0 | 7 | 3 | 0 | 3.66 |
| SP | Kershaw, C.Kershaw, Clayton >> | 33 | 2021 | L | 88 | 8 | 8 | 1 | 4 | 9.20 | .393 | 1.88 | 13.7 | 3.4 | 11.5 | 29.1 | 44 | 30 | 30 | 7 | 11 | 37 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.93 |
| SP | Wainwright, A.Wainwright, Adam >> | 40 | 2021 | R | 80 | 8 | 8 | 2 | 3 | 4.28 | .358 | 1.63 | 11.4 | 3.4 | 8.3 | 48.1 | 61 | 24 | 23 | 4 | 18 | 44 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 3.50 |
| SP | McKenzie, T.McKenzie, Triston >> | 23 | 2021 | R | 78 | 8 | 8 | 5 | 3 | 3.79 | .313 | 1.34 | 5.7 | 6.4 | 7.6 | 38.0 | 24 | 16 | 16 | 6 | 27 | 32 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 5.58 |
| RP | Boxberger, B.Boxberger, Brad >> | 33 | 2021 | R | 82 | 23 | 0 | 1 | 0 | 2.64 | .287 | 1.17 | 6.9 | 3.9 | 8.4 | 30.2 | 23 | 9 | 9 | 4 | 13 | 28 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 4.27 |
| RP | Kennedy, I.Kennedy, Ian >> | 37 | 2021 | R | 68 | 21 | 0 | 1 | 1 | 3.21 | .243 | 0.89 | 4.8 | 3.2 | 9.0 | 28.0 | 15 | 10 | 10 | 3 | 10 | 28 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.68 |
| RP | Harper, R.Harper, Ryne >> | 32 | 2021 | R | 59 | 19 | 0 | 2 | 2 | 5.31 | .299 | 1.18 | 8.1 | 2.7 | 6.3 | 20.1 | 18 | 12 | 12 | 3 | 6 | 14 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 4.75 |
| SP | Gonzales, M.Gonzales, Marco >> | 29 | 2021 | L | 63 | 11 | 0 | 3 | 2 | 7.41 | .354 | 1.53 | 9.0 | 4.8 | 6.4 | 17.0 | 17 | 14 | 14 | 4 | 9 | 12 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 6.59 |