| SP | Alcantara, S.Alcantara, Sandy # >> | 25 | 2021 | R | 78 | 9 | 9 | 3 | 4 | 6.79 | .343 | 1.51 | 11.6 | 2.1 | 7.9 | 51.2 | 66 | 40 | 39 | 10 | 12 | 45 | 0 | 0 | 0 | 0 | 4 | 3 | 0 | 4.67 |
| SP | Ohtani, S.Ohtani, Shohei $$ >> | 26 | 2021 | R | 90 | 8 | 8 | 1 | 3 | 6.42 | .365 | 1.62 | 9.9 | 5.0 | 11.9 | 40.2 | 44 | 30 | 29 | 7 | 22 | 53 | 0 | 0 | 0 | 0 | 2 | 4 | 3 | 4.58 |
| CL | Iglesias, R.Iglesias, Raisel >> | 31 | 2021 | R | 94 | 16 | 0 | 4 | 2 | 2.08 | .358 | 1.67 | 13.8 | 1.6 | 12.2 | 17.1 | 26 | 7 | 4 | 0 | 3 | 23 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 0.82 |
| RP | Jansen, K.Jansen, Kenley >> | 33 | 2021 | R | 93 | 23 | 0 | 3 | 2 | 4.30 | .221 | 0.85 | 4.3 | 3.4 | 9.3 | 29.1 | 14 | 16 | 14 | 3 | 11 | 30 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 3.41 |
| SU | Rodriguez, R.Rodriguez, Richard >> | 31 | 2021 | R | 77 | 18 | 0 | 1 | 1 | 6.05 | .370 | 1.66 | 11.8 | 3.3 | 8.5 | 19.1 | 25 | 14 | 13 | 5 | 7 | 18 | 0 | 3 | 4 | 0 | 0 | 2 | 2 | 5.95 |
| RP | Loaisiga, J.Loaisiga, Jonathan >> | 26 | 2021 | R | 73 | 20 | 0 | 1 | 1 | 2.96 | .317 | 1.35 | 9.0 | 3.3 | 8.3 | 27.1 | 27 | 12 | 9 | 3 | 10 | 25 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.81 |
| SP | Bumgarner, M.Bumgarner, Madison >> | 31 | 2021 | L | 54 | 8 | 8 | 2 | 3 | 4.78 | .300 | 1.24 | 7.7 | 3.5 | 8.1 | 49.0 | 42 | 26 | 26 | 10 | 19 | 44 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 5.14 |
| SP | Greinke, Z.Greinke, Zack >> | 38 | 2021 | R | 52 | 6 | 0 | 1 | 2 | 4.38 | .403 | 1.78 | 14.3 | 2.3 | 9.0 | 12.1 | 19 | 11 | 6 | 4 | 3 | 12 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 6.83 |
| RP | Lopez, R.Lopez, Reynaldo >> | 27 | 2021 | R | 85 | 18 | 0 | 0 | 0 | 3.77 | .285 | 1.10 | 7.5 | 2.3 | 7.3 | 31.0 | 26 | 13 | 13 | 6 | 8 | 25 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 4.97 |