| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 99 | 6 | 6 | 4 | 1 | 2.72 | .237 | 0.91 | 6.1 | 2.1 | 10.3 | 43.0 | 29 | 13 | 13 | 5 | 10 | 49 | 1 | 0 | 0 | 1 | 4 | 1 | 0 | 3.00 |
| SP | Musgrove, J.Musgrove, Joseph # >> | 28 | 2021 | R | 87 | 5 | 5 | 2 | 2 | 7.33 | .357 | 1.56 | 10.3 | 3.7 | 11.0 | 27.0 | 31 | 22 | 22 | 6 | 11 | 33 | 1 | 0 | 0 | 0 | 2 | 3 | 1 | 5.00 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 99 | 12 | 0 | 0 | 1 | 7.24 | .414 | 2.12 | 15.9 | 4.2 | 15.2 | 13.2 | 23 | 11 | 11 | 1 | 6 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 2.00 |
| RP | Pressly, R.Pressly, Ryan >> | 32 | 2021 | R | 88 | 12 | 0 | 0 | 0 | 2.65 | .227 | 0.88 | 4.8 | 3.2 | 9.5 | 17.0 | 9 | 5 | 5 | 3 | 6 | 18 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.24 |
| RP | Williams, D.Williams, Devin >> | 26 | 2021 | R | 77 | 11 | 0 | 1 | 1 | 5.79 | .323 | 1.36 | 7.1 | 5.1 | 10.9 | 14.0 | 11 | 9 | 9 | 0 | 8 | 17 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.50 |
| RP | Chapman, A.Chapman, Aroldis >> | 33 | 2021 | L | 67 | 12 | 0 | 1 | 0 | 2.93 | .281 | 1.11 | 6.6 | 3.6 | 11.4 | 15.1 | 11 | 6 | 5 | 2 | 6 | 19 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 3.60 |
| RP | Brentz, J.Brentz, Jake >> | 26 | 2021 | L | 61 | 11 | 0 | 2 | 0 | 4.50 | .357 | 1.67 | 6.0 | 9.0 | 9.8 | 12.0 | 8 | 6 | 6 | 1 | 12 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.92 |
| SP | Gilbert, L.Gilbert, Logan >> | 24 | 2021 | R | 61 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Bumgarner, M.Bumgarner, Madison >> | 31 | 2021 | L | 54 | 4 | 0 | 0 | 0 | 0.93 | .256 | 0.93 | 4.0 | 5.0 | 9.0 | 9.2 | 4 | 1 | 1 | 0 | 5 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.00 |