| SP | Peralta, F.Peralta, Freddy >> | 25 | 2021 | R | 98 | 9 | 9 | 2 | 3 | 2.55 | .287 | 1.17 | 5.8 | 4.8 | 10.4 | 53.0 | 34 | 15 | 15 | 6 | 28 | 61 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 3.87 |
| SP | Cortes Jr., N.Cortes Jr., Nestor # >> | 26 | 2021 | L | 86 | 9 | 9 | 2 | 2 | 6.32 | .369 | 1.76 | 11.7 | 4.1 | 9.7 | 37.0 | 48 | 26 | 26 | 6 | 17 | 40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.32 |
| SP | Urquidy, J.Urquidy, Jose >> | 26 | 2021 | R | 85 | 8 | 8 | 3 | 1 | 4.40 | .302 | 1.23 | 8.8 | 2.3 | 9.0 | 47.0 | 46 | 23 | 23 | 7 | 12 | 47 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | 3.89 |
| SP | McCullers, L.McCullers, Lance >> | 28 | 2021 | R | 73 | 8 | 8 | 5 | 1 | 4.37 | .324 | 1.44 | 8.8 | 4.2 | 10.1 | 47.1 | 46 | 23 | 23 | 5 | 22 | 53 | 0 | 0 | 0 | 0 | 3 | 0 | 2 | 3.53 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 99 | 20 | 0 | 2 | 2 | 3.14 | .283 | 1.15 | 5.1 | 5.5 | 12.9 | 28.2 | 16 | 10 | 10 | 4 | 17 | 40 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.93 |
| RP | Romano, J.Romano, Jordan >> | 28 | 2021 | R | 88 | 22 | 0 | 2 | 2 | 2.30 | .248 | 0.93 | 5.5 | 2.9 | 9.6 | 31.1 | 19 | 8 | 8 | 1 | 10 | 33 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2.45 |
| RP | Williams, D.Williams, Devin >> | 26 | 2021 | R | 77 | 23 | 0 | 3 | 2 | 4.67 | .404 | 2.00 | 11.7 | 6.3 | 11.3 | 27.0 | 35 | 16 | 14 | 4 | 19 | 34 | 0 | 0 | 3 | 0 | 0 | 1 | 1 | 4.63 |
| RP | Chapman, A.Chapman, Aroldis >> | 33 | 2021 | L | 67 | 24 | 0 | 1 | 1 | 2.67 | .254 | 0.96 | 5.7 | 3.0 | 11.1 | 30.1 | 19 | 9 | 9 | 1 | 10 | 37 | 0 | 3 | 1 | 0 | 0 | 2 | 2 | 2.17 |
| RP | Brentz, J.Brentz, Jake >> | 26 | 2021 | L | 61 | 20 | 0 | 1 | 0 | 6.41 | .344 | 1.53 | 6.6 | 7.6 | 9.5 | 19.2 | 14 | 14 | 14 | 2 | 16 | 20 | 0 | 3 | 0 | 0 | 0 | 1 | 2 | 4.95 |