| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 99 | 9 | 9 | 4 | 2 | 3.70 | .280 | 1.15 | 7.9 | 2.5 | 9.5 | 58.1 | 51 | 26 | 24 | 5 | 16 | 61 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 2.90 |
| SP | Wheeler, Z.Wheeler, Zack >> | 31 | 2021 | R | 91 | 9 | 9 | 4 | 5 | 3.75 | .310 | 1.35 | 8.4 | 3.8 | 10.2 | 60.0 | 56 | 30 | 25 | 9 | 25 | 68 | 0 | 0 | 0 | 0 | 6 | 0 | 2 | 3.93 |
| SP | Rogers, T.Rogers, Trevor >> | 23 | 2021 | L | 81 | 8 | 8 | 3 | 4 | 5.89 | .371 | 1.75 | 10.8 | 5.3 | 13.5 | 36.2 | 43 | 26 | 24 | 4 | 21 | 54 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 3.28 |
| SP | Stroman, M.Stroman, Marcus # >> | 30 | 2021 | R | 64 | 8 | 8 | 4 | 2 | 4.85 | .304 | 1.27 | 9.2 | 2.4 | 7.3 | 42.2 | 43 | 23 | 23 | 6 | 11 | 34 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 4.17 |
| SU | McHugh, C.McHugh, Collin >> | 34 | 2021 | R | 89 | 19 | 0 | 2 | 0 | 1.46 | .260 | 0.97 | 7.5 | 1.5 | 9.4 | 24.2 | 20 | 4 | 4 | 2 | 4 | 25 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 2.75 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 75 | 15 | 0 | 1 | 0 | 3.31 | .197 | 0.73 | 4.5 | 2.3 | 12.4 | 16.1 | 8 | 6 | 6 | 1 | 4 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.81 |
| RP | Suarez, R.Suarez, Ranger >> | 25 | 2021 | L | 83 | 16 | 0 | 2 | 0 | 3.47 | .327 | 1.46 | 10.6 | 2.7 | 7.4 | 23.1 | 27 | 14 | 9 | 2 | 7 | 19 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.39 |
| RP | Sulser, C.Sulser, Cole >> | 31 | 2021 | R | 71 | 22 | 0 | 0 | 0 | 3.32 | .321 | 1.42 | 8.1 | 4.7 | 8.5 | 19.0 | 17 | 8 | 7 | 5 | 10 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6.11 |
| RP | Castillo, D.Castillo, Diego >> | 27 | 2021 | R | 90 | 11 | 0 | 1 | 0 | 6.17 | .364 | 1.71 | 10.6 | 5.7 | 12.3 | 11.2 | 13 | 8 | 8 | 2 | 7 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.55 |