| SP | Glasnow, T.Glasnow, Tyler >> | 27 | 2021 | R | 100 | 9 | 9 | 3 | 3 | 4.20 | .300 | 1.25 | 6.5 | 4.8 | 10.7 | 60.0 | 43 | 28 | 28 | 6 | 32 | 71 | 0 | 0 | 0 | 0 | 4 | 2 | 5 | 3.63 |
| SP | Cole, G.Cole, Gerrit # >> | 30 | 2021 | R | 87 | 9 | 9 | 5 | 2 | 3.71 | .260 | 1.02 | 6.9 | 2.4 | 11.0 | 60.2 | 46 | 26 | 25 | 7 | 16 | 73 | 0 | 0 | 0 | 0 | 7 | 2 | 0 | 2.98 |
| SP | Giolito, L.Giolito, Lucas >> | 26 | 2021 | R | 83 | 8 | 8 | 1 | 2 | 5.20 | .322 | 1.38 | 8.0 | 4.4 | 10.0 | 45.0 | 40 | 27 | 26 | 9 | 22 | 50 | 1 | 0 | 0 | 1 | 3 | 2 | 0 | 4.98 |
| RP | Sewald, P.Sewald, Paul >> | 31 | 2021 | R | 91 | 29 | 0 | 2 | 0 | 1.85 | .263 | 0.99 | 5.3 | 3.8 | 12.4 | 24.1 | 14 | 5 | 5 | 3 | 10 | 33 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 3.38 |
| RP | Staumont, J.Staumont, Josh >> | 27 | 2021 | R | 81 | 22 | 0 | 2 | 2 | 4.12 | .306 | 1.27 | 7.6 | 4.3 | 12.3 | 19.2 | 16 | 12 | 9 | 3 | 9 | 26 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.89 |
| RP | Watson, T.Watson, Tony >> | 36 | 2021 | L | 78 | 22 | 0 | 3 | 1 | 3.57 | .321 | 1.42 | 8.5 | 4.8 | 10.1 | 17.2 | 16 | 8 | 7 | 2 | 9 | 19 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3.88 |
| RP | Springs, J.Springs, Jeffrey >> | 28 | 2021 | L | 74 | 15 | 0 | 0 | 1 | 9.53 | .370 | 1.68 | 12.3 | 3.3 | 13.1 | 11.1 | 15 | 12 | 12 | 3 | 4 | 16 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 5.00 |
| RP | Bleier, R.Bleier, Richard >> | 34 | 2021 | L | 68 | 8 | 0 | 1 | 0 | 12.60 | .464 | 2.60 | 19.8 | 3.6 | 3.6 | 5.0 | 11 | 7 | 7 | 4 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 13.80 |