| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 6 | 6 | 3 | 1 | 5.77 | .327 | 1.37 | 10.1 | 2.4 | 14.3 | 34.1 | 38 | 22 | 22 | 7 | 9 | 54 | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 3.56 |
| SP | Wheeler, Z.Wheeler, Zack >> | 31 | 2021 | R | 91 | 6 | 6 | 1 | 3 | 4.50 | .333 | 1.48 | 10.1 | 3.2 | 10.4 | 40.0 | 45 | 20 | 20 | 7 | 14 | 46 | 0 | 0 | 0 | 0 | 5 | 1 | 1 | 4.10 |
| SP | Rogers, T.Rogers, Trevor >> | 23 | 2021 | L | 81 | 6 | 6 | 2 | 1 | 4.40 | .374 | 1.79 | 8.7 | 7.8 | 9.9 | 30.2 | 29 | 15 | 15 | 0 | 26 | 33 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 3.40 |
| SP | DeSclafani, A.DeSclafani, Anthony >> | 31 | 2021 | R | 74 | 6 | 6 | 3 | 2 | 3.44 | .267 | 1.04 | 8.0 | 1.5 | 8.3 | 36.2 | 32 | 14 | 14 | 7 | 6 | 33 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.36 |
| SP | Stroman, M.Stroman, Marcus # >> | 30 | 2021 | R | 64 | 7 | 5 | 1 | 2 | 5.58 | .328 | 1.40 | 9.6 | 3.3 | 6.6 | 30.2 | 32 | 19 | 19 | 5 | 11 | 22 | 0 | 1 | 0 | 0 | 1 | 2 | 0 | 5.00 |
| RP | Clase, E.Clase, Emmanuel >> | 23 | 2021 | R | 85 | 14 | 0 | 1 | 1 | 2.38 | .218 | 0.84 | 6.1 | 1.6 | 8.2 | 22.2 | 15 | 6 | 6 | 1 | 4 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.32 |
| RP | McHugh, C.McHugh, Collin >> | 34 | 2021 | R | 89 | 14 | 0 | 1 | 0 | 2.18 | .184 | 0.68 | 5.0 | 1.4 | 8.1 | 20.2 | 11 | 5 | 5 | 3 | 3 | 18 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.60 |
| RP | Rodriguez, R.Rodriguez, Richard >> | 31 | 2021 | R | 77 | 11 | 0 | 1 | 3 | 2.38 | .244 | 0.88 | 5.7 | 2.5 | 10.6 | 11.1 | 7 | 3 | 3 | 0 | 3 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1.73 |
| RP | Springs, J.Springs, Jeffrey >> | 28 | 2021 | L | 74 | 8 | 0 | 1 | 0 | 12.00 | .455 | 2.50 | 15.0 | 7.5 | 12.0 | 6.0 | 10 | 8 | 8 | 2 | 5 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.17 |
| CL | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 99 | 12 | 0 | 0 | 1 | 3.38 | .298 | 1.28 | 6.2 | 5.5 | 9.7 | 13.1 | 9 | 5 | 5 | 1 | 8 | 14 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 3.69 |
| SU | Knebel, C.Knebel, Corey >> | 29 | 2021 | R | 90 | 14 | 0 | 0 | 1 | 3.14 | .283 | 1.12 | 4.5 | 5.8 | 12.2 | 14.1 | 7 | 5 | 5 | 2 | 9 | 19 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 4.29 |