| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 9 | 9 | 3 | 1 | 2.69 | .273 | 1.06 | 7.1 | 2.6 | 12.9 | 60.1 | 47 | 21 | 18 | 7 | 17 | 86 | 0 | 0 | 0 | 0 | 9 | 4 | 0 | 2.70 |
| SP | Urias, J.Urias, Julio # >> | 24 | 2021 | L | 89 | 9 | 9 | 3 | 1 | 3.45 | .277 | 1.12 | 8.2 | 1.9 | 8.8 | 57.1 | 52 | 22 | 22 | 3 | 12 | 56 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 2.46 |
| SP | Darvish, Y.Darvish, Yu >> | 34 | 2021 | R | 82 | 8 | 8 | 3 | 3 | 3.98 | .306 | 1.23 | 8.6 | 2.5 | 8.6 | 43.0 | 41 | 19 | 19 | 8 | 12 | 41 | 0 | 0 | 0 | 0 | 3 | 4 | 3 | 4.63 |
| SP | Skubal, T.Skubal, Tarik >> | 24 | 2021 | L | 45 | 10 | 8 | 0 | 4 | 6.57 | .373 | 1.70 | 11.4 | 3.9 | 10.0 | 37.0 | 47 | 28 | 27 | 9 | 16 | 41 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 5.49 |
| RP | Chavez, J.Chavez, Jesse >> | 38 | 2021 | R | 87 | 25 | 0 | 5 | 1 | 2.25 | .267 | 1.09 | 7.0 | 2.8 | 10.4 | 32.0 | 25 | 8 | 8 | 0 | 10 | 37 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1.63 |
| RP | Bender, A.Bender, Anthony >> | 26 | 2021 | R | 79 | 21 | 0 | 3 | 0 | 2.08 | .257 | 0.96 | 4.2 | 4.5 | 10.7 | 26.0 | 12 | 6 | 6 | 1 | 13 | 31 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 2.85 |
| RP | Jackson, L.Jackson, Luke >> | 29 | 2021 | R | 70 | 19 | 0 | 1 | 1 | 4.00 | .333 | 1.44 | 6.5 | 6.5 | 11.0 | 18.0 | 13 | 8 | 8 | 1 | 13 | 22 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 3.61 |
| RP | Pressly, R.Pressly, Ryan >> | 32 | 2021 | R | 88 | 13 | 0 | 0 | 1 | 5.73 | .400 | 1.91 | 10.6 | 6.5 | 15.5 | 11.0 | 13 | 7 | 7 | 1 | 8 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.18 |
| RP | Treinen, B.Treinen, Blake >> | 33 | 2021 | R | 91 | 9 | 0 | 0 | 1 | 4.50 | .268 | 1.00 | 6.3 | 2.7 | 9.9 | 10.0 | 7 | 5 | 5 | 1 | 3 | 11 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.30 |
| CL | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 99 | 19 | 0 | 2 | 2 | 4.05 | .310 | 1.35 | 7.7 | 4.5 | 11.7 | 20.0 | 17 | 9 | 9 | 4 | 10 | 26 | 0 | 11 | 2 | 0 | 0 | 0 | 2 | 4.50 |