| SP | Burnes, C.Burnes, Corbin >> | 26 | 2021 | R | 97 | 9 | 9 | 1 | 3 | 3.91 | .312 | 1.34 | 10.0 | 2.0 | 10.0 | 53.0 | 59 | 24 | 23 | 6 | 12 | 59 | 0 | 0 | 0 | 0 | 5 | 1 | 2 | 2.98 |
| SP | Gausman, K.Gausman, Kevin >> | 30 | 2021 | R | 92 | 9 | 9 | 2 | 4 | 3.63 | .299 | 1.23 | 8.5 | 2.5 | 9.8 | 57.0 | 54 | 23 | 23 | 5 | 16 | 62 | 0 | 0 | 0 | 0 | 5 | 3 | 0 | 2.96 |
| SP | Montas, F.Montas, Frankie >> | 28 | 2021 | R | 69 | 7 | 7 | 1 | 2 | 4.93 | .331 | 1.41 | 8.8 | 4.0 | 9.9 | 38.1 | 37 | 25 | 21 | 9 | 17 | 42 | 0 | 0 | 0 | 0 | 4 | 3 | 2 | 5.45 |
| SP | Bieber, S.Bieber, Shane $ >> | 26 | 2021 | R | 66 | 8 | 8 | 2 | 4 | 5.11 | .353 | 1.59 | 11.0 | 3.3 | 10.4 | 44.0 | 54 | 25 | 25 | 7 | 16 | 51 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 3.98 |
| CL | Hendriks, L.Hendriks, Liam >> | 32 | 2021 | R | 100 | 18 | 0 | 1 | 4 | 3.38 | .300 | 1.29 | 7.5 | 4.5 | 11.5 | 18.2 | 15 | 7 | 7 | 2 | 9 | 23 | 0 | 7 | 1 | 0 | 0 | 0 | 0 | 3.39 |
| RP | Knebel, C.Knebel, Corey >> | 29 | 2021 | R | 90 | 21 | 0 | 0 | 2 | 3.22 | .212 | 0.81 | 4.9 | 2.5 | 7.4 | 22.1 | 12 | 8 | 8 | 3 | 6 | 18 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.95 |
| RP | Adams, A.Adams, Austin $ >> | 30 | 2021 | R | 80 | 19 | 0 | 1 | 0 | 2.87 | .277 | 1.09 | 6.6 | 3.6 | 9.0 | 15.2 | 11 | 5 | 5 | 0 | 6 | 15 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 2.40 |
| RP | Bednar, D.Bednar, David >> | 26 | 2021 | R | 92 | 23 | 0 | 1 | 1 | 8.22 | .446 | 2.35 | 14.4 | 7.2 | 7.8 | 15.1 | 24 | 17 | 14 | 1 | 12 | 13 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.73 |
| RP | Clase, E.Clase, Emmanuel >> | 23 | 2021 | R | 85 | 7 | 0 | 2 | 0 | 6.75 | .429 | 2.06 | 16.2 | 3.6 | 10.8 | 5.1 | 9 | 7 | 4 | 1 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.00 |
| RP | Steckenrider, D.Steckenrider, Drew >> | 30 | 2021 | R | 72 | 2 | 0 | 0 | 0 | 13.50 | .500 | 3.00 | 27.0 | 9.0 | 0.0 | 1.1 | 3 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 |
| RP | Pomeranz, D.Pomeranz, Drew >> | 32 | 2021 | L | 69 | 1 | 0 | 0 | 0 | 0.00 | .167 | 0.60 | 9.0 | 0.0 | 0.0 | 1.2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |