| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 26 | 26 | 8 | 10 | 3.77 | .297 | 1.22 | 8.1 | 2.9 | 8.8 | 157.2 | 142 | 67 | 66 | 22 | 51 | 153 | 2 | 0 | 0 | 0 | 15 | 7 | 0 | 3.98 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 25 | 25 | 7 | 12 | 5.73 | .323 | 1.38 | 9.5 | 2.9 | 8.7 | 132.0 | 139 | 86 | 84 | 22 | 43 | 127 | 1 | 0 | 0 | 0 | 11 | 7 | 0 | 4.38 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 25 | 25 | 15 | 4 | 3.33 | .247 | 0.97 | 7.1 | 1.6 | 4.9 | 175.2 | 139 | 67 | 65 | 24 | 32 | 96 | 8 | 0 | 0 | 2 | 16 | 2 | 4 | 4.27 |
| CL | Kimbrel, C.Kimbrel, Craig † $$ >> | 24 | 2012 | R | 100 | 52 | 0 | 4 | 3 | 2.29 | .240 | 0.92 | 5.2 | 3.1 | 11.0 | 59.0 | 34 | 16 | 15 | 2 | 20 | 72 | 0 | 29 | 2 | 0 | 0 | 2 | 5 | 2.12 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 45 | 0 | 3 | 1 | 4.14 | .294 | 1.25 | 6.8 | 4.5 | 9.5 | 54.1 | 41 | 25 | 25 | 7 | 27 | 57 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.07 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 75 | 34 | 0 | 1 | 3 | 3.57 | .313 | 1.34 | 9.0 | 3.2 | 8.8 | 40.1 | 40 | 17 | 16 | 3 | 14 | 39 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.15 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 23 | 0 | 2 | 1 | 7.36 | .365 | 1.73 | 9.8 | 5.7 | 9.0 | 22.0 | 24 | 19 | 18 | 5 | 14 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5.86 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 25 | 0 | 0 | 1 | 2.20 | .216 | 0.80 | 5.6 | 1.7 | 8.4 | 32.2 | 20 | 10 | 8 | 3 | 6 | 30 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.00 |
| SP | Maloney, J.Maloney, Jim # >> | 23 | 1963 | R | 30 | 23 | 15 | 10 | 6 | 4.22 | .289 | 1.19 | 7.4 | 3.4 | 7.4 | 132.1 | 108 | 63 | 62 | 15 | 50 | 108 | 3 | 0 | 0 | 0 | 7 | 3 | 2 | 4.05 |