| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 93 | 26 | 26 | 9 | 13 | 3.70 | .288 | 1.20 | 8.7 | 2.2 | 8.5 | 184.2 | 177 | 79 | 76 | 11 | 44 | 174 | 2 | 0 | 0 | 0 | 18 | 3 | 7 | 2.65 |
| SP | Maddux, G.Maddux, Greg $$ >> | 29 | 1995 | R | 89 | 26 | 26 | 10 | 9 | 3.61 | .291 | 1.22 | 8.5 | 2.6 | 5.1 | 194.2 | 183 | 79 | 78 | 15 | 55 | 109 | 8 | 0 | 0 | 2 | 15 | 2 | 3 | 3.76 |
| SP | Snell, B.Snell, Blake † $ >> | 25 | 2018 | L | 81 | 25 | 25 | 16 | 6 | 2.61 | .256 | 0.99 | 5.7 | 3.3 | 7.4 | 165.2 | 104 | 51 | 48 | 12 | 60 | 136 | 1 | 0 | 0 | 1 | 18 | 7 | 2 | 3.52 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 25 | 25 | 10 | 10 | 4.35 | .315 | 1.37 | 7.9 | 4.5 | 8.3 | 151.0 | 132 | 73 | 73 | 24 | 75 | 139 | 0 | 0 | 0 | 0 | 13 | 1 | 0 | 4.74 |
| SP | Fernandez, S.Fernandez, Sid $ >> | 23 | 1985 | L | 49 | 24 | 24 | 10 | 8 | 4.25 | .304 | 1.30 | 6.5 | 5.3 | 7.7 | 154.2 | 111 | 75 | 73 | 13 | 90 | 131 | 1 | 0 | 0 | 1 | 12 | 2 | 2 | 4.19 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 77 | 0 | 5 | 3 | 2.93 | .295 | 1.24 | 9.3 | 2.0 | 7.1 | 67.2 | 69 | 26 | 22 | 6 | 15 | 53 | 0 | 7 | 3 | 0 | 0 | 1 | 0 | 3.30 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 50 | 0 | 2 | 2 | 3.16 | .303 | 1.29 | 8.5 | 3.2 | 8.1 | 51.1 | 48 | 19 | 18 | 5 | 18 | 46 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 3.59 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 49 | 37 | 0 | 1 | 2 | 3.40 | .279 | 1.13 | 6.9 | 3.5 | 7.2 | 39.2 | 30 | 15 | 15 | 4 | 15 | 31 | 0 | 11 | 0 | 0 | 0 | 1 | 1 | 3.97 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 61 | 0 | 3 | 1 | 2.28 | .249 | 0.97 | 5.1 | 3.7 | 7.8 | 51.1 | 29 | 13 | 13 | 5 | 21 | 44 | 0 | 4 | 1 | 0 | 0 | 1 | 3 | 3.84 |