| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 26 | 26 | 14 | 4 | 3.17 | .274 | 1.11 | 7.6 | 2.4 | 8.5 | 176.0 | 148 | 62 | 62 | 18 | 47 | 167 | 3 | 0 | 0 | 1 | 16 | 4 | 2 | 3.30 |
| SP | Alexander, P.Alexander, Pete † >> | 28 | 1915 | R | 88 | 25 | 25 | 12 | 5 | 2.52 | .256 | 1.01 | 6.6 | 2.6 | 4.8 | 182.1 | 133 | 58 | 51 | 9 | 52 | 97 | 6 | 0 | 0 | 2 | 20 | 3 | 3 | 3.48 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 25 | 25 | 8 | 10 | 4.93 | .315 | 1.36 | 10.1 | 2.1 | 9.0 | 146.0 | 164 | 86 | 80 | 17 | 34 | 146 | 1 | 0 | 0 | 0 | 12 | 3 | 2 | 3.27 |
| SP | Lundgren, C.Lundgren, Carl # >> | 27 | 1907 | R | 43 | 25 | 25 | 13 | 9 | 4.40 | .331 | 1.44 | 7.6 | 5.4 | 3.9 | 161.2 | 136 | 85 | 79 | 12 | 97 | 69 | 3 | 0 | 0 | 0 | 15 | 7 | 4 | 5.05 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 65 | 0 | 7 | 2 | 3.05 | .265 | 1.08 | 6.5 | 3.3 | 7.9 | 76.2 | 55 | 26 | 26 | 8 | 28 | 67 | 0 | 8 | 3 | 0 | 0 | 0 | 0 | 3.71 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 43 | 0 | 5 | 2 | 6.23 | .356 | 1.66 | 8.6 | 6.5 | 9.6 | 43.1 | 41 | 32 | 30 | 7 | 31 | 46 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 5.14 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 34 | 0 | 3 | 1 | 1.98 | .281 | 1.15 | 6.4 | 4.0 | 6.6 | 41.0 | 29 | 11 | 9 | 2 | 18 | 30 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.56 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 31 | 0 | 1 | 1 | 3.46 | .278 | 1.15 | 7.2 | 3.2 | 6.0 | 39.0 | 31 | 18 | 15 | 4 | 14 | 26 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 4.08 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 61 | 0 | 6 | 0 | 2.14 | .250 | 0.97 | 6.4 | 2.3 | 8.0 | 63.0 | 45 | 16 | 15 | 3 | 16 | 56 | 0 | 38 | 3 | 0 | 0 | 2 | 1 | 2.70 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 15 | 0 | 2 | 4 | 5.79 | .331 | 1.46 | 9.4 | 3.7 | 4.6 | 70.0 | 73 | 55 | 45 | 8 | 29 | 36 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.79 |