| SP | Tiant, L.Tiant, Luis $ >> | 28 | 1968 | R | 97 | 15 | 15 | 11 | 2 | 2.88 | .260 | 1.03 | 5.7 | 3.6 | 8.0 | 112.2 | 71 | 38 | 36 | 13 | 45 | 99 | 4 | 0 | 0 | 1 | 11 | 3 | 3 | 4.03 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 15 | 15 | 12 | 2 | 3.57 | .281 | 1.15 | 7.7 | 2.8 | 6.8 | 108.1 | 92 | 43 | 43 | 10 | 33 | 82 | 2 | 0 | 0 | 0 | 10 | 2 | 2 | 3.66 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 15 | 15 | 3 | 6 | 7.03 | .336 | 1.51 | 10.2 | 3.3 | 8.5 | 73.0 | 83 | 57 | 57 | 15 | 27 | 69 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 4.93 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 80 | 15 | 15 | 8 | 4 | 3.98 | .294 | 1.23 | 8.0 | 3.1 | 7.8 | 104.0 | 92 | 50 | 46 | 15 | 36 | 90 | 3 | 0 | 0 | 0 | 9 | 2 | 6 | 4.24 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 15 | 15 | 5 | 4 | 5.63 | .329 | 1.41 | 8.3 | 4.5 | 9.7 | 86.1 | 79 | 54 | 54 | 13 | 43 | 93 | 0 | 0 | 0 | 0 | 5 | 5 | 3 | 4.48 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 10 | 0 | 1 | 0 | 3.46 | .291 | 1.23 | 7.6 | 3.5 | 9.0 | 13.0 | 11 | 6 | 5 | 2 | 5 | 13 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.15 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 8 | 0 | 0 | 0 | 2.08 | .257 | 1.04 | 6.8 | 3.4 | 10.1 | 8.2 | 6 | 2 | 2 | 0 | 3 | 9 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1.88 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 11 | 0 | 0 | 1 | 2.70 | .310 | 1.35 | 10.4 | 2.1 | 12.5 | 13.1 | 15 | 4 | 4 | 1 | 3 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.92 |