| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 35 | 35 | 15 | 8 | 3.67 | .259 | 1.03 | 7.3 | 2.0 | 9.1 | 238.0 | 192 | 101 | 97 | 22 | 53 | 240 | 1 | 0 | 0 | 1 | 23 | 5 | 0 | 2.92 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 34 | 34 | 11 | 13 | 4.71 | .322 | 1.40 | 9.8 | 2.9 | 5.2 | 246.2 | 268 | 134 | 129 | 33 | 78 | 143 | 7 | 0 | 0 | 0 | 16 | 6 | 6 | 4.61 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 81 | 33 | 33 | 16 | 13 | 3.47 | .299 | 1.25 | 8.4 | 2.9 | 4.6 | 251.2 | 234 | 124 | 97 | 28 | 81 | 128 | 10 | 0 | 0 | 3 | 20 | 7 | 5 | 4.48 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 32 | 32 | 12 | 15 | 4.74 | .318 | 1.36 | 8.7 | 3.6 | 4.4 | 218.1 | 211 | 124 | 115 | 28 | 87 | 107 | 2 | 0 | 0 | 0 | 15 | 7 | 2 | 4.98 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 31 | 31 | 9 | 11 | 5.59 | .351 | 1.60 | 10.6 | 3.8 | 4.3 | 204.1 | 241 | 132 | 127 | 21 | 86 | 98 | 2 | 0 | 0 | 0 | 11 | 5 | 6 | 4.72 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 81 | 0 | 5 | 5 | 3.99 | .313 | 1.35 | 9.1 | 3.1 | 9.5 | 103.2 | 104 | 48 | 46 | 11 | 36 | 109 | 0 | 12 | 6 | 0 | 0 | 2 | 0 | 3.38 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 73 | 0 | 2 | 4 | 1.65 | .242 | 0.94 | 4.8 | 3.7 | 7.8 | 98.0 | 52 | 18 | 18 | 4 | 40 | 85 | 0 | 16 | 3 | 0 | 0 | 2 | 4 | 3.08 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 53 | 0 | 6 | 8 | 6.51 | .341 | 1.50 | 10.5 | 3.1 | 8.8 | 55.1 | 64 | 40 | 40 | 12 | 19 | 54 | 0 | 3 | 6 | 0 | 0 | 3 | 3 | 5.07 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 34 | 0 | 3 | 5 | 2.95 | .274 | 1.13 | 6.7 | 3.7 | 7.6 | 39.2 | 29 | 14 | 13 | 3 | 16 | 33 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 3.54 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 11 | 0 | 1 | 1 | 2.89 | .317 | 1.39 | 9.0 | 4.0 | 4.0 | 9.1 | 9 | 3 | 3 | 0 | 4 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.44 |