| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 35 | 35 | 7 | 16 | 4.42 | .313 | 1.35 | 8.7 | 3.5 | 8.1 | 220.0 | 213 | 112 | 108 | 22 | 85 | 198 | 2 | 0 | 0 | 0 | 18 | 3 | 7 | 3.70 |
| SP | Alexander, P.Alexander, Pete † >> | 28 | 1915 | R | 88 | 34 | 34 | 17 | 9 | 3.47 | .268 | 1.08 | 7.5 | 2.2 | 5.3 | 233.2 | 195 | 91 | 90 | 25 | 58 | 136 | 9 | 0 | 0 | 2 | 20 | 4 | 1 | 4.03 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 13 | 9 | 4.74 | .323 | 1.42 | 8.6 | 4.2 | 7.0 | 172.2 | 165 | 103 | 91 | 28 | 80 | 133 | 0 | 0 | 0 | 0 | 17 | 2 | 4 | 5.00 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 32 | 32 | 15 | 8 | 4.02 | .305 | 1.30 | 8.4 | 3.3 | 6.9 | 190.1 | 177 | 87 | 85 | 20 | 70 | 146 | 2 | 0 | 0 | 1 | 21 | 3 | 2 | 3.98 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 29 | 29 | 13 | 6 | 3.70 | .316 | 1.37 | 7.7 | 4.7 | 4.5 | 187.1 | 160 | 86 | 77 | 11 | 97 | 93 | 5 | 0 | 0 | 2 | 17 | 3 | 5 | 4.37 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 82 | 0 | 3 | 5 | 2.74 | .260 | 1.04 | 7.2 | 2.2 | 7.9 | 85.1 | 68 | 30 | 26 | 11 | 21 | 75 | 0 | 33 | 3 | 0 | 0 | 1 | 0 | 3.69 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 85 | 0 | 4 | 7 | 3.59 | .275 | 1.11 | 7.5 | 2.5 | 7.4 | 85.1 | 71 | 34 | 34 | 16 | 24 | 70 | 0 | 6 | 2 | 0 | 0 | 2 | 0 | 4.72 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 60 | 0 | 3 | 1 | 3.41 | .308 | 1.29 | 8.6 | 3.2 | 8.0 | 60.2 | 57 | 23 | 23 | 6 | 21 | 53 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 3.73 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 16 | 2 | 4 | 3 | 4.95 | .335 | 1.46 | 9.0 | 4.3 | 6.0 | 36.1 | 36 | 20 | 20 | 5 | 17 | 24 | 0 | 2 | 1 | 0 | 1 | 2 | 1 | 5.06 |