| SP | Martinez, P.Martinez, Pedro $ >> | 29 | 2000 | R | 100 | 15 | 15 | 7 | 6 | 3.49 | .256 | 1.02 | 7.3 | 2.0 | 8.6 | 100.2 | 81 | 41 | 39 | 8 | 22 | 95 | 3 | 0 | 0 | 1 | 10 | 1 | 1 | 2.83 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 15 | 15 | 5 | 7 | 6.57 | .343 | 1.54 | 11.6 | 2.4 | 9.9 | 76.2 | 98 | 57 | 56 | 10 | 20 | 84 | 1 | 0 | 0 | 1 | 4 | 2 | 1 | 3.37 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 45 | 0 | 2 | 4 | 4.27 | .319 | 1.37 | 9.3 | 3.1 | 10.0 | 52.2 | 54 | 25 | 25 | 10 | 18 | 58 | 0 | 17 | 3 | 0 | 0 | 2 | 2 | 4.42 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 45 | 0 | 3 | 1 | 3.99 | .281 | 1.12 | 6.9 | 3.2 | 9.3 | 56.1 | 43 | 27 | 25 | 9 | 20 | 58 | 0 | 1 | 4 | 0 | 0 | 3 | 0 | 4.25 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 44 | 0 | 4 | 0 | 3.02 | .278 | 1.14 | 8.3 | 2.0 | 10.7 | 53.2 | 49 | 18 | 18 | 5 | 12 | 63 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 2.58 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 39 | 0 | 1 | 1 | 3.66 | .320 | 1.41 | 8.8 | 4.1 | 8.4 | 46.2 | 45 | 22 | 19 | 4 | 21 | 43 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3.63 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 36 | 0 | 1 | 0 | 6.64 | .347 | 1.57 | 10.7 | 3.4 | 8.8 | 42.0 | 50 | 31 | 31 | 12 | 16 | 41 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.98 |