| SP | Verlander, J.Verlander, Justin $$ >> | 36 | 2019 | R | 99 | 19 | 19 | 7 | 9 | 3.11 | .291 | 1.23 | 7.7 | 3.4 | 7.9 | 127.1 | 109 | 52 | 44 | 12 | 48 | 112 | 1 | 0 | 0 | 0 | 14 | 0 | 5 | 3.60 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 18 | 18 | 9 | 6 | 5.24 | .355 | 1.63 | 11.5 | 3.2 | 8.0 | 111.2 | 142 | 67 | 65 | 21 | 40 | 99 | 1 | 0 | 0 | 0 | 6 | 2 | 1 | 4.81 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 18 | 18 | 6 | 5 | 4.95 | .314 | 1.36 | 9.7 | 2.6 | 5.1 | 96.1 | 103 | 55 | 53 | 17 | 28 | 54 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 5.08 |
| SP | Hunter, C.Hunter, Catfish † >> | 26 | 1972 | R | 81 | 17 | 17 | 10 | 7 | 3.35 | .291 | 1.22 | 7.9 | 3.1 | 5.9 | 129.0 | 113 | 51 | 48 | 13 | 45 | 85 | 4 | 0 | 0 | 0 | 12 | 1 | 3 | 4.06 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 17 | 17 | 5 | 8 | 5.53 | .373 | 1.76 | 10.6 | 5.3 | 7.4 | 96.0 | 113 | 69 | 59 | 15 | 56 | 79 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 5.20 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 29 | 0 | 3 | 3 | 5.54 | .328 | 1.42 | 8.7 | 4.2 | 10.7 | 26.0 | 25 | 16 | 16 | 0 | 12 | 31 | 0 | 20 | 2 | 0 | 0 | 1 | 1 | 2.12 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 40 | 0 | 0 | 3 | 3.35 | .268 | 1.08 | 6.5 | 3.2 | 7.8 | 51.0 | 37 | 19 | 19 | 6 | 18 | 44 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 3.92 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 34 | 0 | 2 | 0 | 2.50 | .255 | 1.00 | 5.8 | 3.3 | 10.8 | 36.0 | 23 | 13 | 10 | 1 | 13 | 43 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.14 |
| SU | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 24 | 0 | 0 | 0 | 4.81 | .270 | 1.11 | 6.8 | 3.4 | 8.6 | 24.1 | 18 | 13 | 13 | 4 | 9 | 23 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 4.38 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 28 | 0 | 0 | 0 | 1.95 | .239 | 0.94 | 5.7 | 3.0 | 10.0 | 27.2 | 17 | 6 | 6 | 2 | 9 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.74 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 13 | 0 | 2 | 2 | 5.61 | .306 | 1.31 | 9.4 | 2.5 | 4.6 | 51.1 | 53 | 32 | 32 | 8 | 14 | 26 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.90 |