| SP | Greinke, Z.Greinke, Zack $ >> | 32 | 2015 | R | 94 | 19 | 19 | 4 | 10 | 5.28 | .324 | 1.41 | 9.5 | 3.3 | 5.2 | 117.2 | 123 | 78 | 69 | 14 | 43 | 68 | 2 | 0 | 0 | 0 | 10 | 3 | 4 | 4.57 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 18 | 18 | 11 | 4 | 3.29 | .285 | 1.18 | 7.5 | 3.2 | 5.1 | 120.1 | 100 | 45 | 44 | 9 | 42 | 68 | 1 | 0 | 0 | 1 | 14 | 2 | 1 | 3.94 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 17 | 17 | 6 | 8 | 5.02 | .311 | 1.33 | 9.1 | 2.9 | 3.5 | 122.0 | 123 | 73 | 68 | 20 | 39 | 48 | 1 | 0 | 0 | 0 | 6 | 3 | 1 | 5.38 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 16 | 16 | 5 | 5 | 4.68 | .348 | 1.58 | 8.5 | 5.8 | 8.4 | 100.0 | 94 | 63 | 52 | 13 | 64 | 93 | 0 | 0 | 0 | 0 | 6 | 2 | 2 | 4.81 |
| CL | Benoit, J.Benoit, Joaquin $ >> | 33 | 2010 | R | 95 | 29 | 0 | 2 | 7 | 3.45 | .277 | 1.12 | 8.4 | 1.9 | 10.0 | 28.2 | 26 | 16 | 11 | 7 | 6 | 31 | 0 | 16 | 3 | 0 | 0 | 1 | 1 | 4.79 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 32 | 0 | 0 | 1 | 4.41 | .307 | 1.30 | 7.7 | 4.2 | 7.4 | 34.2 | 29 | 18 | 17 | 5 | 16 | 28 | 0 | 5 | 3 | 0 | 0 | 1 | 1 | 4.76 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 28 | 0 | 2 | 1 | 2.05 | .282 | 1.18 | 5.9 | 4.8 | 8.3 | 26.1 | 17 | 6 | 6 | 1 | 14 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.27 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 14 | 0 | 0 | 2 | 4.30 | .279 | 1.16 | 8.4 | 2.6 | 8.4 | 14.2 | 13 | 7 | 7 | 3 | 4 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.79 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 9 | 0 | 1 | 0 | 2.35 | .233 | 0.78 | 5.1 | 2.6 | 6.4 | 7.2 | 4 | 2 | 2 | 0 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2.86 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 19 | 0 | 0 | 0 | 4.13 | .258 | 1.00 | 7.9 | 1.1 | 9.0 | 24.0 | 21 | 12 | 11 | 2 | 3 | 24 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.58 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 4 | 1 | 1 | 0 | 6.49 | .347 | 1.56 | 11.1 | 3.1 | 7.6 | 26.1 | 32 | 25 | 19 | 3 | 9 | 22 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 3.96 |