| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 19 | 19 | 7 | 3 | 3.02 | .258 | 1.01 | 5.8 | 3.4 | 9.8 | 125.1 | 80 | 45 | 42 | 9 | 47 | 136 | 1 | 0 | 0 | 0 | 14 | 4 | 0 | 2.98 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 18 | 18 | 7 | 8 | 4.89 | .310 | 1.34 | 9.9 | 2.2 | 5.0 | 103.0 | 113 | 65 | 56 | 17 | 25 | 57 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 4.80 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 17 | 17 | 5 | 9 | 5.07 | .332 | 1.45 | 9.4 | 3.6 | 4.7 | 126.0 | 132 | 75 | 71 | 18 | 51 | 66 | 8 | 0 | 0 | 1 | 6 | 5 | 6 | 5.14 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 17 | 17 | 4 | 10 | 5.48 | .331 | 1.45 | 9.6 | 3.6 | 3.9 | 106.2 | 113 | 67 | 65 | 15 | 42 | 46 | 1 | 0 | 0 | 0 | 8 | 3 | 3 | 5.25 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 46 | 0 | 2 | 1 | 2.79 | .287 | 1.21 | 7.6 | 3.3 | 9.0 | 58.0 | 49 | 26 | 18 | 5 | 21 | 58 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.21 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 38 | 0 | 1 | 1 | 4.44 | .318 | 1.40 | 8.3 | 4.5 | 8.3 | 48.2 | 44 | 28 | 24 | 9 | 24 | 44 | 0 | 8 | 3 | 0 | 0 | 0 | 2 | 5.10 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 31 | 0 | 5 | 3 | 2.70 | .276 | 1.12 | 7.8 | 2.5 | 9.0 | 36.2 | 31 | 11 | 11 | 3 | 10 | 36 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 3.00 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 19 | 0 | 0 | 4 | 3.79 | .301 | 1.29 | 7.2 | 4.6 | 5.1 | 35.2 | 28 | 15 | 15 | 2 | 18 | 20 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 4.14 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 9 | 0 | 1 | 2 | 2.89 | .325 | 1.45 | 8.5 | 5.0 | 8.5 | 18.2 | 17 | 6 | 6 | 1 | 10 | 17 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.50 |