| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 16 | 16 | 5 | 5 | 4.45 | .327 | 1.43 | 8.0 | 4.9 | 8.2 | 89.0 | 79 | 46 | 44 | 8 | 48 | 81 | 0 | 0 | 0 | 0 | 8 | 3 | 2 | 4.07 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 16 | 16 | 7 | 5 | 5.32 | .309 | 1.34 | 10.4 | 1.7 | 5.6 | 93.0 | 107 | 55 | 55 | 9 | 18 | 58 | 1 | 0 | 0 | 0 | 6 | 0 | 2 | 3.59 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 16 | 16 | 6 | 8 | 4.55 | .333 | 1.46 | 9.7 | 3.4 | 5.0 | 97.0 | 105 | 55 | 49 | 15 | 37 | 54 | 2 | 0 | 0 | 1 | 8 | 3 | 1 | 5.13 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 35 | 0 | 1 | 4 | 3.41 | .288 | 1.22 | 7.3 | 3.6 | 8.3 | 37.0 | 30 | 14 | 14 | 7 | 15 | 34 | 0 | 20 | 4 | 0 | 0 | 0 | 2 | 4.84 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 44 | 0 | 8 | 0 | 4.07 | .288 | 1.19 | 6.8 | 4.1 | 7.5 | 48.2 | 36 | 22 | 22 | 5 | 22 | 40 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.13 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 31 | 0 | 3 | 3 | 3.06 | .325 | 1.44 | 6.2 | 6.9 | 6.9 | 35.1 | 24 | 12 | 12 | 3 | 27 | 27 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.89 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 24 | 0 | 2 | 0 | 3.00 | .257 | 1.04 | 7.0 | 2.3 | 9.0 | 27.0 | 21 | 9 | 9 | 5 | 7 | 27 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.19 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 18 | 0 | 1 | 2 | 3.78 | .383 | 1.86 | 10.1 | 7.3 | 9.0 | 16.2 | 18 | 8 | 7 | 1 | 13 | 16 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.25 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 17 | 0 | 2 | 0 | 4.41 | .269 | 1.10 | 5.6 | 4.5 | 7.3 | 16.1 | 10 | 8 | 8 | 2 | 8 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.50 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 5 | 0 | 0 | 1 | 4.66 | .301 | 1.24 | 7.6 | 3.8 | 6.6 | 19.1 | 16 | 13 | 10 | 0 | 8 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.95 |