| SP | Schilling, C.Schilling, Curt # >> | 36 | 2002 | R | 93 | 5 | 5 | 2 | 3 | 5.01 | .292 | 1.24 | 9.8 | 1.4 | 8.2 | 32.1 | 35 | 19 | 18 | 5 | 5 | 29 | 1 | 0 | 0 | 0 | 2 | 0 | 2 | 3.69 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 75 | 5 | 5 | 1 | 2 | 6.75 | .360 | 1.69 | 11.6 | 3.9 | 10.7 | 21.1 | 27 | 16 | 16 | 5 | 9 | 25 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5.00 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 73 | 4 | 4 | 2 | 0 | 3.66 | .330 | 1.47 | 9.9 | 3.8 | 7.6 | 19.2 | 21 | 8 | 8 | 2 | 8 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.95 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 55 | 4 | 4 | 0 | 2 | 6.66 | .342 | 1.48 | 10.1 | 3.4 | 6.8 | 24.1 | 27 | 18 | 18 | 7 | 9 | 18 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 6.67 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 51 | 4 | 4 | 1 | 1 | 6.45 | .323 | 1.39 | 10.2 | 2.5 | 6.5 | 22.1 | 25 | 16 | 16 | 3 | 6 | 16 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 4.27 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 13 | 0 | 0 | 0 | 5.30 | .317 | 1.39 | 11.0 | 2.0 | 7.5 | 18.2 | 22 | 14 | 11 | 6 | 4 | 15 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 6.33 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 52 | 16 | 0 | 0 | 1 | 2.79 | .310 | 1.24 | 7.0 | 5.0 | 11.0 | 9.2 | 7 | 4 | 3 | 1 | 5 | 11 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 35 | 10 | 0 | 1 | 1 | 2.51 | .259 | 1.05 | 7.1 | 2.6 | 10.9 | 14.1 | 11 | 4 | 4 | 0 | 4 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1.43 |
| RP | Cordero, F.Cordero, Francisco >> | 32 | 2007 | R | 25 | 11 | 0 | 1 | 3 | 5.73 | .389 | 1.91 | 11.5 | 5.7 | 10.6 | 11.0 | 14 | 7 | 7 | 2 | 7 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.91 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 38 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |