| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 11 | 11 | 2 | 6 | 4.23 | .322 | 1.38 | 8.2 | 4.2 | 10.1 | 66.0 | 60 | 32 | 31 | 7 | 31 | 74 | 0 | 0 | 0 | 0 | 6 | 3 | 1 | 3.68 |
| SP | Halladay, R.Halladay, Roy # >> | 28 | 2005 | R | 87 | 11 | 11 | 8 | 2 | 3.53 | .293 | 1.22 | 9.1 | 1.8 | 6.7 | 79.0 | 80 | 35 | 31 | 10 | 16 | 59 | 3 | 0 | 0 | 0 | 7 | 2 | 2 | 3.84 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 10 | 10 | 3 | 5 | 4.48 | .315 | 1.36 | 9.3 | 3.1 | 6.9 | 70.1 | 72 | 36 | 35 | 10 | 24 | 54 | 1 | 0 | 0 | 0 | 5 | 1 | 2 | 4.39 |
| SP | Burnett, A.Burnett, A.J. >> | 25 | 2002 | R | 57 | 10 | 10 | 6 | 2 | 4.11 | .316 | 1.32 | 7.6 | 4.4 | 7.5 | 65.2 | 55 | 33 | 30 | 9 | 32 | 54 | 1 | 0 | 0 | 0 | 6 | 4 | 3 | 4.80 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 51 | 10 | 10 | 3 | 6 | 5.37 | .341 | 1.50 | 11.0 | 2.6 | 6.7 | 58.2 | 71 | 35 | 35 | 5 | 17 | 43 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | 3.67 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 52 | 22 | 0 | 2 | 1 | 5.13 | .347 | 1.59 | 10.4 | 4.2 | 7.3 | 26.1 | 30 | 16 | 15 | 2 | 12 | 21 | 0 | 1 | 2 | 0 | 0 | 0 | 4 | 3.77 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 40 | 18 | 0 | 1 | 0 | 1.83 | .263 | 1.07 | 6.6 | 3.3 | 9.9 | 19.2 | 14 | 4 | 4 | 3 | 7 | 21 | 0 | 5 | 0 | 0 | 0 | 0 | 2 | 3.95 |
| RP | Stewart, S.Stewart, Scott >> | 27 | 2002 | L | 29 | 10 | 0 | 2 | 0 | 5.00 | .341 | 1.56 | 11.0 | 3.0 | 11.0 | 9.0 | 11 | 5 | 5 | 2 | 3 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.44 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 39 | 2 | 0 | 0 | 0 | 2.70 | .333 | 1.50 | 12.0 | 3.0 | 6.0 | 3.1 | 4 | 1 | 1 | 0 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.67 |