| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 29 | 29 | 9 | 10 | 4.32 | .298 | 1.26 | 9.0 | 2.3 | 9.3 | 196.0 | 197 | 97 | 94 | 28 | 50 | 203 | 2 | 0 | 0 | 0 | 14 | 3 | 3 | 3.60 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 73 | 28 | 28 | 5 | 12 | 4.46 | .307 | 1.29 | 7.8 | 3.8 | 6.4 | 169.2 | 147 | 96 | 84 | 28 | 72 | 121 | 0 | 0 | 0 | 0 | 14 | 7 | 0 | 5.12 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 28 | 28 | 11 | 12 | 5.38 | .319 | 1.35 | 10.0 | 2.2 | 6.2 | 179.0 | 199 | 114 | 107 | 38 | 43 | 124 | 1 | 0 | 0 | 0 | 13 | 10 | 8 | 5.26 |
| SP | Maddux, G.Maddux, Greg # >> | 34 | 2000 | R | 58 | 28 | 27 | 10 | 12 | 4.06 | .313 | 1.32 | 9.0 | 2.9 | 6.3 | 188.1 | 189 | 94 | 85 | 29 | 60 | 132 | 5 | 0 | 0 | 1 | 15 | 8 | 1 | 4.69 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 94 | 49 | 0 | 5 | 3 | 1.67 | .250 | 1.00 | 7.5 | 1.5 | 8.5 | 54.0 | 45 | 10 | 10 | 3 | 9 | 51 | 0 | 28 | 1 | 0 | 0 | 0 | 0 | 2.33 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 76 | 0 | 5 | 4 | 3.90 | .299 | 1.24 | 7.4 | 3.8 | 5.0 | 80.2 | 66 | 36 | 35 | 9 | 34 | 44 | 0 | 2 | 4 | 0 | 0 | 3 | 0 | 4.75 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 84 | 65 | 0 | 8 | 2 | 4.45 | .289 | 1.16 | 6.1 | 4.5 | 10.4 | 56.2 | 38 | 29 | 28 | 10 | 28 | 65 | 0 | 0 | 3 | 0 | 0 | 3 | 3 | 4.66 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 67 | 0 | 1 | 0 | 3.26 | .281 | 1.13 | 7.7 | 2.5 | 8.4 | 47.0 | 40 | 18 | 17 | 6 | 13 | 44 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 3.74 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 47 | 0 | 2 | 1 | 2.62 | .280 | 1.14 | 5.8 | 4.5 | 8.2 | 34.1 | 22 | 10 | 10 | 4 | 17 | 31 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 4.29 |
| RP | Sasaki, K.Sasaki, Kazuhiro >> | 33 | 2001 | R | 64 | 33 | 0 | 5 | 2 | 4.99 | .287 | 1.17 | 7.8 | 3.0 | 6.0 | 30.2 | 26 | 17 | 17 | 3 | 10 | 20 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 4.07 |