| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 29 | 29 | 8 | 15 | 4.85 | .313 | 1.32 | 9.6 | 2.3 | 9.3 | 174.1 | 186 | 95 | 94 | 33 | 44 | 180 | 2 | 0 | 0 | 1 | 12 | 8 | 5 | 4.29 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 28 | 28 | 11 | 7 | 3.92 | .296 | 1.24 | 8.0 | 3.2 | 8.3 | 172.1 | 153 | 81 | 75 | 17 | 61 | 158 | 1 | 0 | 0 | 0 | 17 | 3 | 2 | 3.56 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 52 | 0 | 2 | 3 | 4.95 | .307 | 1.30 | 9.2 | 2.6 | 11.1 | 56.1 | 57 | 32 | 31 | 6 | 16 | 69 | 0 | 7 | 6 | 0 | 0 | 2 | 0 | 2.89 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 84 | 71 | 0 | 2 | 5 | 5.30 | .328 | 1.44 | 6.4 | 6.7 | 10.8 | 86.2 | 61 | 52 | 51 | 10 | 64 | 103 | 0 | 1 | 1 | 0 | 0 | 2 | 4 | 4.42 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 70 | 0 | 4 | 1 | 3.47 | .223 | 0.83 | 5.5 | 2.0 | 8.0 | 90.2 | 55 | 36 | 35 | 12 | 20 | 80 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 3.72 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 67 | 49 | 0 | 2 | 4 | 6.96 | .351 | 1.56 | 11.3 | 2.8 | 10.2 | 54.1 | 68 | 42 | 42 | 18 | 17 | 61 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 6.19 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 50 | 47 | 0 | 1 | 3 | 4.62 | .303 | 1.24 | 9.0 | 2.3 | 7.0 | 50.2 | 50 | 26 | 26 | 10 | 13 | 39 | 0 | 1 | 1 | 0 | 0 | 3 | 1 | 5.00 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 24 | 1 | 4 | 5 | 6.52 | .350 | 1.56 | 10.7 | 3.4 | 7.6 | 88.1 | 105 | 64 | 64 | 16 | 33 | 74 | 0 | 0 | 1 | 0 | 0 | 5 | 0 | 4.98 |