| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 99 | 29 | 29 | 8 | 14 | 4.75 | .310 | 1.32 | 9.1 | 2.8 | 8.1 | 168.2 | 169 | 91 | 89 | 17 | 53 | 152 | 2 | 0 | 0 | 0 | 14 | 5 | 7 | 3.54 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 87 | 29 | 29 | 10 | 8 | 3.63 | .289 | 1.19 | 8.1 | 2.7 | 8.9 | 173.2 | 155 | 72 | 70 | 23 | 52 | 171 | 1 | 0 | 0 | 0 | 20 | 5 | 3 | 3.74 |
| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 85 | 28 | 28 | 9 | 7 | 3.91 | .282 | 1.15 | 7.8 | 2.5 | 6.2 | 175.0 | 152 | 78 | 76 | 28 | 49 | 120 | 1 | 0 | 0 | 1 | 17 | 5 | 2 | 4.63 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 76 | 28 | 28 | 10 | 10 | 5.08 | .319 | 1.38 | 9.1 | 3.3 | 9.5 | 168.1 | 170 | 96 | 95 | 24 | 62 | 177 | 1 | 0 | 0 | 0 | 12 | 5 | 9 | 3.95 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 69 | 26 | 26 | 6 | 10 | 5.18 | .339 | 1.48 | 10.1 | 3.3 | 6.1 | 144.1 | 161 | 86 | 83 | 25 | 53 | 97 | 0 | 0 | 0 | 0 | 11 | 8 | 2 | 5.18 |
| CL | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 57 | 0 | 5 | 8 | 3.58 | .295 | 1.24 | 8.3 | 2.9 | 10.8 | 65.1 | 60 | 27 | 26 | 4 | 21 | 78 | 0 | 27 | 5 | 0 | 0 | 1 | 0 | 2.42 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 49 | 0 | 3 | 2 | 4.45 | .251 | 0.97 | 6.7 | 2.2 | 10.8 | 54.2 | 40 | 27 | 27 | 9 | 13 | 65 | 0 | 5 | 6 | 0 | 0 | 2 | 2 | 3.59 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 77 | 0 | 4 | 3 | 2.70 | .243 | 0.94 | 6.8 | 1.7 | 8.9 | 96.2 | 73 | 29 | 29 | 7 | 18 | 95 | 0 | 4 | 1 | 0 | 0 | 2 | 2 | 2.59 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 67 | 32 | 0 | 4 | 2 | 4.42 | .270 | 1.09 | 6.9 | 3.1 | 9.2 | 38.2 | 29 | 20 | 19 | 6 | 13 | 39 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.11 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 50 | 24 | 0 | 4 | 1 | 2.70 | .295 | 1.25 | 9.8 | 1.8 | 7.5 | 36.2 | 39 | 13 | 11 | 5 | 7 | 30 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 3.72 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 54 | 19 | 0 | 6 | 0 | 3.90 | .309 | 1.31 | 9.6 | 2.4 | 5.7 | 80.2 | 85 | 36 | 35 | 6 | 21 | 51 | 0 | 0 | 0 | 0 | 0 | 2 | 7 | 3.56 |