| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 29 | 29 | 10 | 8 | 4.16 | .283 | 1.16 | 8.2 | 2.3 | 9.3 | 179.2 | 163 | 86 | 83 | 30 | 46 | 185 | 2 | 0 | 0 | 0 | 16 | 4 | 5 | 3.95 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 71 | 27 | 27 | 13 | 5 | 4.43 | .333 | 1.47 | 8.6 | 4.7 | 6.0 | 160.2 | 152 | 79 | 79 | 20 | 84 | 106 | 2 | 0 | 0 | 1 | 14 | 5 | 2 | 4.97 |
| RP | Gagne, E.Gagne, Eric # >> | 27 | 2003 | R | 100 | 70 | 0 | 5 | 4 | 4.47 | .295 | 1.25 | 7.7 | 3.6 | 9.8 | 102.2 | 87 | 52 | 51 | 16 | 41 | 111 | 0 | 5 | 4 | 0 | 0 | 1 | 0 | 4.10 |
| RP | Lidge, B.Lidge, Brad † >> | 28 | 2004 | R | 82 | 73 | 0 | 6 | 3 | 3.45 | .282 | 1.15 | 6.3 | 4.1 | 10.2 | 101.2 | 71 | 39 | 39 | 11 | 46 | 114 | 0 | 10 | 3 | 0 | 0 | 3 | 1 | 3.61 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 56 | 0 | 1 | 4 | 3.28 | .301 | 1.26 | 8.4 | 3.0 | 10.9 | 71.1 | 66 | 28 | 26 | 7 | 24 | 86 | 0 | 6 | 2 | 0 | 0 | 2 | 2 | 2.96 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 69 | 45 | 0 | 2 | 4 | 2.61 | .265 | 1.08 | 5.8 | 3.9 | 10.0 | 62.0 | 40 | 19 | 18 | 5 | 27 | 69 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.13 |
| RP | Takatsu, S.Takatsu, Shingo >> | 36 | 2004 | R | 56 | 39 | 0 | 2 | 3 | 3.38 | .269 | 1.05 | 5.8 | 3.8 | 6.8 | 50.2 | 32 | 19 | 19 | 4 | 21 | 38 | 0 | 3 | 2 | 0 | 0 | 3 | 2 | 3.96 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 55 | 7 | 0 | 2 | 1 | 3.05 | .333 | 1.45 | 8.6 | 5.0 | 8.1 | 20.2 | 19 | 7 | 7 | 2 | 11 | 18 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.30 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 85 | 28 | 0 | 0 | 1 | 5.46 | .288 | 1.21 | 8.1 | 3.1 | 4.7 | 29.2 | 26 | 18 | 18 | 7 | 10 | 15 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 6.14 |