| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 11 | 11 | 8 | 2 | 4.19 | .275 | 1.12 | 7.6 | 2.5 | 7.5 | 73.0 | 62 | 36 | 34 | 15 | 20 | 61 | 2 | 0 | 0 | 2 | 6 | 1 | 1 | 4.86 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 11 | 11 | 6 | 5 | 5.11 | .322 | 1.40 | 9.4 | 3.3 | 8.1 | 68.2 | 71 | 40 | 39 | 10 | 25 | 61 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 4.31 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 80 | 11 | 11 | 3 | 3 | 6.46 | .349 | 1.60 | 10.9 | 3.6 | 9.3 | 62.2 | 75 | 48 | 45 | 16 | 25 | 64 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 5.55 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 10 | 10 | 5 | 3 | 5.48 | .331 | 1.47 | 9.1 | 4.2 | 7.0 | 67.1 | 68 | 41 | 41 | 15 | 31 | 52 | 1 | 0 | 0 | 1 | 4 | 1 | 3 | 5.79 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 56 | 10 | 9 | 3 | 4 | 8.14 | .367 | 1.70 | 13.2 | 2.2 | 6.4 | 45.1 | 66 | 41 | 41 | 13 | 11 | 32 | 0 | 0 | 1 | 0 | 2 | 2 | 0 | 6.20 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 30 | 0 | 3 | 0 | 4.24 | .297 | 1.26 | 9.5 | 1.9 | 10.3 | 34.0 | 36 | 18 | 16 | 1 | 7 | 39 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1.71 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 25 | 0 | 2 | 0 | 6.58 | .381 | 1.81 | 10.4 | 5.9 | 10.4 | 26.0 | 30 | 19 | 19 | 2 | 17 | 30 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3.77 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 18 | 0 | 1 | 0 | 3.32 | .278 | 1.15 | 6.4 | 4.3 | 11.6 | 21.2 | 15 | 8 | 8 | 1 | 10 | 27 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.48 |
| CL | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 99 | 21 | 0 | 0 | 1 | 3.32 | .293 | 1.20 | 7.7 | 3.4 | 10.7 | 21.2 | 18 | 8 | 8 | 4 | 8 | 25 | 0 | 13 | 1 | 0 | 0 | 1 | 0 | 4.38 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 90 | 21 | 0 | 1 | 1 | 6.30 | .355 | 1.65 | 11.7 | 3.2 | 12.2 | 20.0 | 26 | 16 | 14 | 4 | 7 | 27 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.95 |