| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 29 | 29 | 8 | 6 | 4.09 | .302 | 1.27 | 8.1 | 3.4 | 9.5 | 125.1 | 112 | 57 | 57 | 16 | 47 | 132 | 0 | 0 | 0 | 0 | 1 | 4 | 8 | 3.78 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 82 | 28 | 28 | 4 | 12 | 7.68 | .369 | 1.72 | 11.2 | 4.3 | 6.1 | 138.1 | 172 | 123 | 118 | 26 | 66 | 94 | 1 | 0 | 0 | 0 | 8 | 5 | 5 | 5.63 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 76 | 28 | 28 | 7 | 9 | 5.96 | .332 | 1.47 | 10.5 | 2.7 | 8.1 | 167.2 | 195 | 112 | 111 | 26 | 51 | 151 | 0 | 0 | 0 | 0 | 10 | 4 | 3 | 4.20 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 69 | 29 | 28 | 14 | 7 | 5.22 | .332 | 1.46 | 10.3 | 2.9 | 5.8 | 170.2 | 195 | 100 | 99 | 32 | 54 | 109 | 1 | 0 | 0 | 1 | 13 | 6 | 0 | 5.22 |
| SP | Sabathia, C.Sabathia, CC # >> | 28 | 2008 | L | 62 | 26 | 26 | 7 | 10 | 6.37 | .363 | 1.68 | 11.3 | 3.8 | 8.8 | 152.2 | 191 | 109 | 108 | 35 | 65 | 148 | 0 | 0 | 0 | 0 | 9 | 5 | 4 | 5.43 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 94 | 64 | 0 | 4 | 6 | 2.96 | .272 | 1.08 | 6.8 | 3.0 | 8.5 | 73.0 | 55 | 26 | 24 | 6 | 24 | 69 | 0 | 37 | 6 | 0 | 0 | 3 | 2 | 3.29 |
| SU | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 60 | 0 | 4 | 3 | 2.56 | .265 | 1.07 | 4.7 | 5.0 | 6.9 | 56.1 | 29 | 20 | 16 | 4 | 31 | 43 | 0 | 3 | 4 | 0 | 0 | 1 | 1 | 4.11 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 74 | 0 | 7 | 1 | 4.10 | .323 | 1.42 | 9.6 | 3.3 | 6.9 | 98.2 | 104 | 49 | 45 | 9 | 36 | 75 | 0 | 2 | 1 | 0 | 0 | 1 | 5 | 3.80 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 54 | 51 | 0 | 6 | 0 | 3.25 | .310 | 1.30 | 8.1 | 3.7 | 8.3 | 63.2 | 57 | 24 | 23 | 7 | 26 | 58 | 0 | 1 | 1 | 0 | 0 | 3 | 2 | 3.98 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 53 | 0 | 3 | 0 | 1.44 | .194 | 0.71 | 5.2 | 1.2 | 8.7 | 62.1 | 36 | 12 | 10 | 3 | 8 | 60 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.13 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 80 | 34 | 0 | 0 | 2 | 3.03 | .314 | 1.32 | 5.9 | 6.2 | 11.6 | 38.2 | 25 | 18 | 13 | 3 | 26 | 49 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.66 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 86 | 10 | 0 | 0 | 5 | 14.73 | .459 | 2.45 | 16.4 | 5.7 | 9.0 | 11.0 | 20 | 20 | 18 | 7 | 7 | 11 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 11.45 |