| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 11 | 11 | 5 | 3 | 3.26 | .286 | 1.16 | 7.3 | 3.1 | 8.0 | 69.0 | 56 | 26 | 25 | 7 | 24 | 61 | 0 | 0 | 0 | 0 | 8 | 3 | 3 | 3.72 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 80 | 11 | 11 | 5 | 4 | 4.23 | .287 | 1.17 | 8.2 | 2.4 | 6.0 | 78.2 | 71 | 39 | 37 | 5 | 21 | 52 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 3.42 |
| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 84 | 10 | 10 | 4 | 2 | 3.55 | .285 | 1.18 | 6.8 | 3.8 | 6.8 | 66.0 | 50 | 30 | 26 | 11 | 28 | 50 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 4.97 |
| SP | Webb, B.Webb, Brandon # >> | 24 | 2003 | R | 64 | 10 | 10 | 2 | 5 | 7.78 | .324 | 1.42 | 9.0 | 4.0 | 8.3 | 41.2 | 41 | 36 | 36 | 8 | 18 | 38 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 5.07 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 100 | 22 | 0 | 2 | 2 | 3.55 | .283 | 1.18 | 6.8 | 4.0 | 7.9 | 25.1 | 19 | 10 | 10 | 3 | 11 | 22 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 4.12 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 86 | 31 | 0 | 2 | 0 | 4.55 | .355 | 1.65 | 5.9 | 9.3 | 10.6 | 29.2 | 19 | 15 | 15 | 5 | 30 | 34 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 6.00 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 31 | 0 | 1 | 1 | 2.42 | .297 | 1.23 | 6.9 | 4.2 | 9.0 | 26.0 | 20 | 7 | 7 | 3 | 12 | 26 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.00 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 61 | 21 | 0 | 2 | 0 | 3.60 | .211 | 0.75 | 5.4 | 1.4 | 6.8 | 20.0 | 12 | 8 | 8 | 4 | 3 | 15 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.70 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 14 | 0 | 2 | 2 | 6.42 | .344 | 1.46 | 10.1 | 3.3 | 8.5 | 33.2 | 37 | 25 | 24 | 10 | 12 | 31 | 0 | 1 | 0 | 0 | 0 | 4 | 0 | 6.52 |