| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 21 | 21 | 6 | 7 | 4.14 | .307 | 1.32 | 8.0 | 3.9 | 8.9 | 121.2 | 108 | 60 | 56 | 16 | 53 | 120 | 1 | 0 | 0 | 0 | 7 | 1 | 2 | 4.07 |
| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 20 | 20 | 3 | 11 | 5.77 | .340 | 1.51 | 10.6 | 3.0 | 7.6 | 106.0 | 125 | 74 | 68 | 17 | 35 | 90 | 0 | 0 | 0 | 0 | 4 | 4 | 2 | 4.49 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 19 | 19 | 2 | 10 | 5.63 | .341 | 1.52 | 11.5 | 2.2 | 4.9 | 110.1 | 141 | 74 | 69 | 17 | 27 | 60 | 3 | 0 | 0 | 0 | 6 | 3 | 3 | 4.74 |
| SU | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 42 | 0 | 4 | 1 | 5.72 | .320 | 1.41 | 10.4 | 2.3 | 9.5 | 50.1 | 58 | 34 | 32 | 11 | 13 | 53 | 0 | 2 | 5 | 0 | 0 | 0 | 0 | 4.52 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 88 | 41 | 0 | 5 | 0 | 1.62 | .244 | 0.97 | 6.1 | 2.7 | 8.8 | 44.1 | 30 | 8 | 8 | 2 | 13 | 43 | 0 | 23 | 2 | 0 | 0 | 0 | 0 | 2.52 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 43 | 0 | 3 | 2 | 3.73 | .324 | 1.39 | 9.0 | 3.5 | 7.2 | 41.0 | 41 | 18 | 17 | 4 | 16 | 33 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 3.98 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 30 | 0 | 0 | 1 | 3.90 | .287 | 1.21 | 7.9 | 3.1 | 6.2 | 32.1 | 28 | 14 | 14 | 7 | 11 | 22 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 5.50 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 51 | 19 | 0 | 1 | 1 | 5.40 | .278 | 1.15 | 8.6 | 2.1 | 6.4 | 21.2 | 20 | 13 | 13 | 2 | 5 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.52 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 6 | 0 | 1 | 0 | 2.70 | .293 | 1.20 | 7.0 | 3.9 | 4.7 | 23.1 | 18 | 7 | 7 | 2 | 10 | 12 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.52 |