| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 21 | 21 | 11 | 2 | 2.50 | .280 | 1.16 | 7.7 | 2.7 | 7.7 | 154.2 | 132 | 46 | 43 | 8 | 47 | 131 | 1 | 0 | 0 | 0 | 15 | 1 | 5 | 2.91 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 22 | 19 | 5 | 5 | 5.35 | .330 | 1.48 | 9.8 | 3.5 | 5.4 | 99.1 | 108 | 60 | 59 | 11 | 39 | 59 | 0 | 0 | 0 | 0 | 8 | 0 | 1 | 4.43 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 86 | 63 | 0 | 7 | 1 | 4.28 | .320 | 1.37 | 10.7 | 1.7 | 7.5 | 73.2 | 87 | 36 | 35 | 12 | 14 | 61 | 0 | 7 | 5 | 0 | 0 | 3 | 0 | 4.16 |
| SU | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 52 | 0 | 4 | 5 | 5.47 | .308 | 1.31 | 8.1 | 3.6 | 8.6 | 74.0 | 67 | 46 | 45 | 11 | 30 | 71 | 0 | 3 | 3 | 0 | 0 | 2 | 0 | 4.31 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 52 | 0 | 3 | 2 | 3.34 | .286 | 1.18 | 7.7 | 3.1 | 7.7 | 56.2 | 48 | 22 | 21 | 5 | 19 | 48 | 0 | 6 | 1 | 0 | 0 | 1 | 5 | 3.52 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 44 | 0 | 2 | 6 | 6.70 | .365 | 1.70 | 10.8 | 4.8 | 7.2 | 41.2 | 49 | 33 | 31 | 6 | 22 | 33 | 0 | 4 | 1 | 0 | 0 | 1 | 3 | 4.98 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 52 | 39 | 0 | 0 | 4 | 8.60 | .369 | 1.76 | 12.2 | 3.6 | 6.6 | 45.0 | 61 | 45 | 43 | 14 | 18 | 33 | 0 | 3 | 2 | 0 | 0 | 0 | 3 | 6.78 |
| RP | Fingers, R.Fingers, Rollie >> | 35 | 1981 | R | 51 | 6 | 0 | 0 | 0 | 2.57 | .300 | 1.29 | 9.0 | 2.6 | 0.0 | 7.0 | 7 | 2 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.71 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 4 | 4 | 1 | 3 | 7.17 | .333 | 1.50 | 11.6 | 2.1 | 7.3 | 21.1 | 27 | 17 | 17 | 4 | 5 | 17 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4.57 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |