| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 21 | 21 | 10 | 9 | 3.97 | .276 | 1.13 | 8.5 | 1.7 | 9.2 | 156.1 | 148 | 75 | 69 | 25 | 29 | 159 | 5 | 0 | 0 | 1 | 9 | 2 | 2 | 3.64 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 19 | 19 | 4 | 7 | 3.70 | .299 | 1.25 | 8.6 | 2.8 | 5.6 | 104.2 | 99 | 47 | 43 | 17 | 32 | 65 | 0 | 0 | 0 | 0 | 9 | 3 | 0 | 4.88 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 19 | 19 | 7 | 11 | 5.74 | .353 | 1.63 | 10.7 | 4.0 | 5.6 | 122.1 | 145 | 83 | 78 | 20 | 54 | 76 | 2 | 0 | 0 | 0 | 5 | 1 | 3 | 5.24 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 20 | 19 | 9 | 10 | 5.06 | .330 | 1.44 | 9.7 | 3.3 | 4.9 | 110.1 | 119 | 66 | 62 | 16 | 40 | 60 | 0 | 0 | 1 | 0 | 9 | 4 | 2 | 5.00 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 49 | 0 | 1 | 0 | 3.17 | .302 | 1.24 | 7.0 | 4.2 | 7.9 | 71.0 | 55 | 26 | 25 | 8 | 33 | 62 | 0 | 3 | 2 | 0 | 0 | 4 | 0 | 4.28 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 92 | 47 | 0 | 6 | 1 | 2.83 | .239 | 0.91 | 5.9 | 2.4 | 9.3 | 63.2 | 41 | 20 | 20 | 9 | 17 | 65 | 0 | 8 | 2 | 0 | 0 | 2 | 0 | 3.70 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 37 | 0 | 0 | 2 | 5.36 | .346 | 1.49 | 9.0 | 4.5 | 9.7 | 40.1 | 40 | 26 | 24 | 6 | 20 | 43 | 0 | 4 | 3 | 0 | 0 | 4 | 2 | 4.60 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 31 | 0 | 3 | 1 | 7.68 | .391 | 1.88 | 12.3 | 4.6 | 5.5 | 41.0 | 56 | 40 | 35 | 7 | 21 | 25 | 0 | 2 | 1 | 0 | 0 | 2 | 3 | 5.68 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 18 | 0 | 0 | 0 | 5.40 | .398 | 1.92 | 10.1 | 7.9 | 9.6 | 16.2 | 18 | 10 | 10 | 1 | 14 | 17 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.50 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 20 | 0 | 1 | 1 | 2.88 | .292 | 1.24 | 9.0 | 2.2 | 8.6 | 25.0 | 25 | 9 | 8 | 2 | 6 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.84 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 5 | 0 | 0 | 0 | 1.50 | .217 | 0.83 | 7.5 | 0.0 | 1.5 | 6.0 | 5 | 2 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.67 |