| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 11 | 11 | 7 | 4 | 3.98 | .269 | 1.09 | 7.0 | 2.9 | 4.9 | 72.1 | 56 | 33 | 32 | 8 | 23 | 39 | 2 | 0 | 0 | 1 | 6 | 1 | 2 | 4.36 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 10 | 10 | 2 | 4 | 7.69 | .352 | 1.57 | 10.8 | 3.4 | 5.6 | 50.1 | 60 | 43 | 43 | 8 | 19 | 31 | 0 | 0 | 0 | 0 | 1 | 3 | 2 | 5.16 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 10 | 10 | 6 | 3 | 3.15 | .252 | 1.01 | 7.3 | 1.8 | 8.6 | 74.1 | 60 | 26 | 26 | 8 | 15 | 71 | 4 | 0 | 0 | 1 | 6 | 0 | 1 | 3.09 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 13 | 10 | 3 | 5 | 4.04 | .314 | 1.32 | 9.8 | 2.2 | 4.6 | 71.1 | 77 | 32 | 32 | 8 | 17 | 36 | 3 | 1 | 0 | 0 | 5 | 4 | 0 | 4.34 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 20 | 0 | 1 | 3 | 5.23 | .303 | 1.26 | 9.9 | 1.8 | 9.9 | 20.2 | 22 | 13 | 12 | 3 | 4 | 22 | 0 | 10 | 0 | 0 | 0 | 1 | 0 | 3.50 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 19 | 0 | 0 | 1 | 2.84 | .288 | 1.21 | 4.7 | 6.2 | 9.9 | 19.0 | 10 | 6 | 6 | 3 | 13 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.89 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 19 | 0 | 1 | 0 | 7.32 | .404 | 2.03 | 12.3 | 6.6 | 8.5 | 19.2 | 26 | 17 | 16 | 7 | 14 | 18 | 0 | 1 | 3 | 0 | 0 | 0 | 3 | 8.11 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 18 | 0 | 1 | 1 | 5.29 | .346 | 1.53 | 9.0 | 4.8 | 5.8 | 17.0 | 17 | 10 | 10 | 1 | 9 | 11 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.24 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 13 | 0 | 0 | 0 | 2.70 | .231 | 0.90 | 6.8 | 1.7 | 9.0 | 16.2 | 12 | 9 | 5 | 4 | 3 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.81 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 6 | 0 | 0 | 1 | 8.25 | .368 | 1.71 | 12.4 | 3.0 | 6.4 | 24.0 | 33 | 23 | 22 | 1 | 8 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.25 |