| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 20 | 20 | 8 | 7 | 4.06 | .286 | 1.20 | 7.8 | 3.0 | 8.4 | 130.2 | 113 | 64 | 59 | 14 | 44 | 121 | 0 | 0 | 0 | 0 | 12 | 0 | 1 | 3.55 |
| SP | Kershaw, C.Kershaw, Clayton # >> | 28 | 2016 | L | 99 | 20 | 20 | 11 | 6 | 2.75 | .237 | 0.90 | 6.6 | 1.5 | 8.3 | 147.1 | 108 | 46 | 45 | 13 | 24 | 136 | 4 | 0 | 0 | 1 | 16 | 5 | 2 | 2.89 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 19 | 19 | 6 | 8 | 3.71 | .284 | 1.18 | 8.3 | 2.3 | 5.1 | 136.0 | 125 | 57 | 56 | 11 | 35 | 77 | 3 | 0 | 0 | 0 | 14 | 2 | 1 | 3.74 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 19 | 19 | 8 | 10 | 4.25 | .282 | 1.18 | 8.2 | 2.4 | 8.5 | 131.1 | 120 | 62 | 62 | 19 | 35 | 123 | 4 | 0 | 0 | 2 | 10 | 0 | 1 | 3.81 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 19 | 19 | 7 | 5 | 3.55 | .270 | 1.09 | 6.6 | 3.3 | 7.7 | 121.2 | 89 | 50 | 48 | 20 | 44 | 103 | 0 | 0 | 0 | 0 | 13 | 2 | 2 | 4.59 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 42 | 0 | 2 | 4 | 1.82 | .256 | 1.01 | 6.0 | 3.2 | 7.4 | 39.2 | 26 | 9 | 8 | 4 | 14 | 32 | 0 | 26 | 1 | 0 | 0 | 1 | 1 | 3.85 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 43 | 0 | 3 | 0 | 3.79 | .296 | 1.21 | 6.9 | 4.0 | 5.9 | 38.0 | 29 | 16 | 16 | 2 | 17 | 25 | 0 | 3 | 2 | 0 | 0 | 2 | 1 | 3.87 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 28 | 0 | 2 | 1 | 3.72 | .310 | 1.34 | 7.4 | 4.7 | 7.8 | 29.0 | 24 | 12 | 12 | 6 | 15 | 25 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 5.52 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 6 | 0 | 1 | 2 | 6.35 | .452 | 2.47 | 19.8 | 5.4 | 3.6 | 5.2 | 11 | 4 | 4 | 3 | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 11.80 |