| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 34 | 34 | 18 | 9 | 4.00 | .296 | 1.25 | 8.3 | 3.0 | 4.6 | 229.2 | 211 | 110 | 102 | 29 | 76 | 117 | 5 | 0 | 0 | 2 | 18 | 3 | 6 | 4.66 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 33 | 33 | 11 | 13 | 5.29 | .310 | 1.32 | 9.2 | 2.7 | 7.5 | 192.1 | 196 | 118 | 113 | 26 | 57 | 160 | 1 | 0 | 0 | 0 | 14 | 6 | 7 | 4.08 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 33 | 33 | 15 | 12 | 4.49 | .283 | 1.17 | 8.5 | 2.1 | 8.3 | 220.1 | 207 | 121 | 110 | 38 | 51 | 203 | 5 | 0 | 0 | 1 | 19 | 3 | 3 | 4.14 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 79 | 34 | 31 | 12 | 14 | 4.80 | .322 | 1.38 | 9.9 | 2.6 | 5.1 | 208.0 | 228 | 117 | 111 | 21 | 60 | 118 | 5 | 1 | 0 | 0 | 13 | 9 | 0 | 4.17 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 68 | 0 | 7 | 7 | 3.56 | .265 | 1.07 | 7.7 | 2.0 | 8.3 | 68.1 | 58 | 28 | 27 | 10 | 15 | 63 | 0 | 39 | 4 | 0 | 0 | 1 | 1 | 3.76 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 73 | 0 | 0 | 1 | 2.63 | .298 | 1.26 | 5.4 | 6.0 | 10.7 | 75.1 | 45 | 25 | 22 | 7 | 50 | 89 | 0 | 5 | 4 | 0 | 0 | 1 | 2 | 3.88 |
| RP | Boxberger, B.Boxberger, Brad # >> | 26 | 2014 | R | 83 | 68 | 0 | 5 | 3 | 4.34 | .315 | 1.37 | 8.6 | 3.8 | 9.0 | 76.2 | 73 | 44 | 37 | 15 | 32 | 76 | 0 | 1 | 5 | 0 | 0 | 1 | 6 | 4.87 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 59 | 0 | 7 | 1 | 3.69 | .293 | 1.20 | 6.9 | 3.8 | 7.8 | 61.0 | 47 | 27 | 25 | 4 | 26 | 53 | 0 | 1 | 1 | 0 | 0 | 3 | 1 | 3.54 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 48 | 0 | 1 | 1 | 2.98 | .286 | 1.15 | 8.8 | 1.6 | 7.7 | 57.1 | 56 | 23 | 19 | 8 | 10 | 49 | 0 | 1 | 2 | 0 | 0 | 3 | 0 | 3.79 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 20 | 0 | 3 | 2 | 8.63 | .372 | 1.74 | 12.0 | 3.6 | 6.1 | 72.0 | 96 | 70 | 69 | 13 | 29 | 49 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 5.32 |