| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 21 | 21 | 10 | 7 | 3.41 | .268 | 1.06 | 7.3 | 2.3 | 9.3 | 142.2 | 115 | 56 | 54 | 14 | 36 | 146 | 1 | 0 | 0 | 0 | 16 | 6 | 0 | 3.11 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 20 | 20 | 4 | 8 | 4.21 | .304 | 1.28 | 8.0 | 3.5 | 8.2 | 130.1 | 116 | 63 | 61 | 13 | 51 | 119 | 1 | 0 | 0 | 0 | 11 | 4 | 0 | 3.74 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 85 | 20 | 20 | 11 | 7 | 3.27 | .271 | 1.10 | 7.4 | 2.6 | 3.9 | 151.1 | 124 | 57 | 55 | 15 | 43 | 65 | 3 | 0 | 0 | 0 | 14 | 2 | 3 | 4.32 |
| RP | Benitez, A.Benitez, Armando † >> | 32 | 2004 | R | 82 | 61 | 0 | 12 | 1 | 2.94 | .267 | 1.05 | 5.7 | 3.9 | 6.2 | 79.2 | 50 | 26 | 26 | 7 | 34 | 54 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 4.19 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 58 | 0 | 2 | 1 | 3.57 | .273 | 1.11 | 6.7 | 3.3 | 8.0 | 63.0 | 47 | 25 | 25 | 8 | 23 | 56 | 0 | 4 | 1 | 0 | 0 | 1 | 7 | 4.02 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 30 | 0 | 1 | 1 | 3.26 | .242 | 0.92 | 5.7 | 2.7 | 8.1 | 30.1 | 19 | 11 | 11 | 5 | 9 | 27 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.37 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 26 | 0 | 3 | 0 | 1.73 | .221 | 0.83 | 2.5 | 5.0 | 6.5 | 36.1 | 10 | 7 | 7 | 2 | 20 | 26 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 4.03 |
| CL | Marmol, C.Marmol, Carlos † >> | 26 | 2008 | R | 71 | 47 | 0 | 1 | 1 | 2.42 | .256 | 1.03 | 5.6 | 3.8 | 6.2 | 48.1 | 30 | 13 | 13 | 5 | 20 | 33 | 0 | 27 | 2 | 0 | 0 | 0 | 1 | 4.23 |