| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 21 | 21 | 9 | 11 | 3.60 | .288 | 1.19 | 7.4 | 3.4 | 8.8 | 152.1 | 125 | 64 | 61 | 17 | 57 | 148 | 5 | 0 | 0 | 1 | 14 | 3 | 0 | 3.69 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 20 | 20 | 4 | 9 | 5.09 | .313 | 1.35 | 8.5 | 3.6 | 4.7 | 111.1 | 105 | 64 | 63 | 21 | 45 | 58 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 5.68 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 12 | 8 | 2 | 5 | 5.77 | .351 | 1.58 | 9.9 | 4.4 | 6.4 | 73.1 | 80 | 53 | 47 | 12 | 36 | 52 | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 5.32 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 47 | 0 | 3 | 0 | 1.99 | .262 | 1.07 | 6.1 | 3.7 | 9.2 | 49.2 | 33 | 11 | 11 | 2 | 20 | 50 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 2.71 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 39 | 0 | 6 | 1 | 3.69 | .335 | 1.44 | 9.2 | 3.7 | 5.1 | 39.0 | 40 | 18 | 16 | 3 | 16 | 22 | 0 | 2 | 0 | 0 | 0 | 3 | 2 | 4.33 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 55 | 0 | 0 | 1 | 4.66 | .322 | 1.34 | 8.1 | 4.3 | 9.5 | 38.2 | 34 | 20 | 20 | 1 | 18 | 40 | 0 | 9 | 2 | 0 | 0 | 3 | 2 | 2.89 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 13 | 10 | 3 | 8 | 6.42 | .344 | 1.51 | 10.6 | 3.2 | 6.1 | 68.2 | 80 | 49 | 49 | 15 | 24 | 46 | 1 | 0 | 0 | 0 | 2 | 4 | 2 | 5.75 |