| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 24 | 24 | 15 | 5 | 3.10 | .256 | 1.01 | 7.3 | 1.9 | 10.7 | 162.2 | 131 | 61 | 56 | 28 | 34 | 193 | 0 | 0 | 0 | 0 | 14 | 3 | 0 | 3.55 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 23 | 23 | 12 | 8 | 4.10 | .312 | 1.33 | 9.0 | 3.1 | 8.8 | 153.2 | 153 | 75 | 70 | 23 | 52 | 150 | 2 | 0 | 0 | 0 | 15 | 4 | 7 | 4.09 |
| SP | Fernandez, J.Fernandez, Jose † >> | 21 | 2013 | R | 83 | 23 | 23 | 12 | 6 | 3.34 | .294 | 1.21 | 7.1 | 3.8 | 8.8 | 148.1 | 116 | 56 | 55 | 16 | 63 | 145 | 0 | 0 | 0 | 0 | 15 | 6 | 3 | 3.84 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 64 | 0 | 4 | 2 | 1.96 | .262 | 1.04 | 5.3 | 4.1 | 9.0 | 96.2 | 57 | 25 | 21 | 11 | 44 | 96 | 0 | 3 | 2 | 0 | 0 | 2 | 0 | 3.93 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 36 | 0 | 4 | 0 | 3.05 | .277 | 1.15 | 6.3 | 4.1 | 7.4 | 44.1 | 31 | 16 | 15 | 2 | 20 | 36 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.32 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 28 | 0 | 2 | 1 | 2.41 | .246 | 0.95 | 6.3 | 2.5 | 10.4 | 33.2 | 23 | 10 | 9 | 2 | 9 | 38 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 2.39 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 65 | 26 | 0 | 3 | 1 | 3.38 | .304 | 1.31 | 8.0 | 4.2 | 6.6 | 26.2 | 23 | 10 | 10 | 2 | 12 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.92 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 96 | 42 | 0 | 0 | 2 | 2.03 | .250 | 1.00 | 5.2 | 3.8 | 11.7 | 40.0 | 23 | 9 | 9 | 3 | 17 | 52 | 0 | 32 | 3 | 0 | 0 | 0 | 3 | 2.65 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 66 | 10 | 0 | 0 | 0 | 3.45 | .352 | 1.63 | 11.9 | 2.9 | 7.8 | 31.1 | 41 | 23 | 12 | 7 | 10 | 27 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.16 |