| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 85 | 29 | 29 | 17 | 8 | 3.97 | .275 | 1.13 | 7.3 | 2.9 | 6.6 | 208.2 | 169 | 96 | 92 | 27 | 66 | 153 | 7 | 0 | 0 | 0 | 15 | 3 | 4 | 4.21 |
| SP | Liriano, F.Liriano, Francisco # >> | 23 | 2006 | L | 75 | 28 | 28 | 3 | 9 | 6.33 | .338 | 1.52 | 8.9 | 4.8 | 7.8 | 116.2 | 115 | 82 | 82 | 28 | 62 | 100 | 0 | 0 | 0 | 0 | 1 | 2 | 6 | 6.07 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 70 | 29 | 28 | 16 | 9 | 3.47 | .302 | 1.26 | 8.3 | 3.1 | 5.6 | 210.0 | 193 | 81 | 81 | 22 | 72 | 131 | 11 | 0 | 0 | 1 | 19 | 7 | 5 | 4.24 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 44 | 0 | 0 | 2 | 3.67 | .309 | 1.30 | 9.0 | 2.9 | 8.6 | 41.2 | 41 | 17 | 17 | 7 | 13 | 39 | 0 | 3 | 3 | 0 | 0 | 2 | 0 | 4.41 |
| RP | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 87 | 72 | 0 | 9 | 1 | 2.17 | .212 | 0.79 | 5.6 | 1.5 | 10.2 | 95.1 | 59 | 24 | 23 | 9 | 16 | 108 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 2.53 |
| RP | Percival, T.Percival, Troy $ >> | 26 | 1995 | R | 80 | 59 | 0 | 8 | 3 | 4.95 | .295 | 1.23 | 7.1 | 4.0 | 9.7 | 63.2 | 50 | 37 | 35 | 14 | 28 | 68 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 5.16 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 39 | 0 | 2 | 1 | 3.22 | .276 | 1.07 | 8.0 | 1.8 | 9.2 | 44.2 | 39 | 16 | 16 | 8 | 9 | 45 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4.14 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 65 | 27 | 0 | 1 | 0 | 3.19 | .317 | 1.39 | 9.0 | 3.8 | 9.3 | 36.2 | 36 | 13 | 13 | 7 | 15 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.72 |