| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 13 | 13 | 7 | 4 | 3.35 | .265 | 1.06 | 7.6 | 2.0 | 10.1 | 83.1 | 70 | 31 | 31 | 4 | 18 | 93 | 1 | 0 | 0 | 1 | 9 | 2 | 0 | 2.11 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 12 | 12 | 7 | 3 | 3.25 | .271 | 1.11 | 7.3 | 2.8 | 9.4 | 88.2 | 71 | 33 | 32 | 9 | 27 | 92 | 3 | 0 | 0 | 1 | 8 | 1 | 2 | 3.19 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 73 | 12 | 12 | 6 | 5 | 3.94 | .296 | 1.24 | 8.5 | 2.7 | 8.4 | 77.2 | 73 | 35 | 34 | 11 | 23 | 72 | 1 | 0 | 0 | 1 | 6 | 2 | 2 | 3.96 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 77 | 12 | 12 | 2 | 6 | 6.09 | .342 | 1.54 | 9.5 | 4.4 | 5.7 | 68.0 | 72 | 47 | 46 | 9 | 33 | 43 | 0 | 0 | 0 | 0 | 5 | 1 | 2 | 4.96 |
| CL | Adams, M.Adams, Mike $ >> | 31 | 2009 | R | 99 | 29 | 0 | 0 | 2 | 2.84 | .216 | 0.83 | 4.0 | 3.6 | 10.4 | 25.1 | 11 | 8 | 8 | 3 | 10 | 29 | 0 | 22 | 0 | 0 | 0 | 0 | 0 | 3.44 |
| SU | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 92 | 23 | 0 | 0 | 1 | 2.39 | .240 | 0.95 | 5.2 | 3.5 | 10.7 | 26.1 | 15 | 7 | 7 | 2 | 10 | 31 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 2.77 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 81 | 14 | 0 | 2 | 2 | 3.38 | .342 | 1.50 | 7.3 | 6.2 | 8.4 | 16.0 | 13 | 6 | 6 | 1 | 11 | 15 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.19 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 81 | 11 | 0 | 0 | 0 | 3.38 | .319 | 1.41 | 9.9 | 3.6 | 9.9 | 10.2 | 11 | 4 | 4 | 1 | 4 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.30 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 69 | 7 | 0 | 0 | 1 | 5.00 | .341 | 1.56 | 13.0 | 1.0 | 10.0 | 9.0 | 13 | 5 | 5 | 2 | 1 | 10 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.00 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 66 | 11 | 0 | 3 | 0 | 5.80 | .371 | 1.71 | 11.8 | 3.9 | 9.3 | 35.2 | 46 | 23 | 23 | 9 | 15 | 36 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.74 |