| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 98 | 34 | 34 | 9 | 17 | 4.69 | .302 | 1.27 | 9.0 | 2.5 | 7.8 | 264.2 | 263 | 147 | 138 | 45 | 73 | 229 | 10 | 0 | 0 | 2 | 12 | 7 | 2 | 4.39 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 33 | 33 | 8 | 13 | 4.91 | .315 | 1.35 | 9.5 | 2.6 | 4.2 | 187.0 | 198 | 105 | 102 | 25 | 54 | 87 | 0 | 0 | 0 | 0 | 10 | 6 | 3 | 4.77 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 80 | 32 | 32 | 10 | 11 | 4.25 | .292 | 1.21 | 8.2 | 2.7 | 5.2 | 237.1 | 216 | 119 | 112 | 35 | 71 | 136 | 7 | 0 | 0 | 1 | 16 | 7 | 1 | 4.76 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 32 | 32 | 9 | 15 | 5.94 | .336 | 1.49 | 10.4 | 3.1 | 4.7 | 218.1 | 252 | 150 | 144 | 31 | 74 | 115 | 4 | 0 | 0 | 0 | 11 | 6 | 4 | 4.89 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 65 | 31 | 31 | 5 | 13 | 5.55 | .338 | 1.51 | 9.5 | 4.1 | 4.6 | 181.2 | 192 | 123 | 112 | 21 | 82 | 92 | 1 | 0 | 0 | 0 | 14 | 4 | 1 | 4.92 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 78 | 0 | 5 | 6 | 3.42 | .275 | 1.13 | 7.9 | 2.4 | 8.8 | 110.2 | 96 | 44 | 42 | 15 | 29 | 107 | 0 | 4 | 5 | 0 | 0 | 1 | 4 | 3.65 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 62 | 0 | 5 | 5 | 5.50 | .323 | 1.43 | 8.4 | 4.5 | 8.1 | 72.0 | 67 | 46 | 44 | 17 | 36 | 65 | 0 | 9 | 4 | 0 | 0 | 0 | 0 | 5.76 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 37 | 0 | 1 | 3 | 2.17 | .247 | 0.99 | 3.7 | 5.3 | 7.3 | 49.2 | 20 | 12 | 12 | 3 | 29 | 40 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 3.94 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 56 | 32 | 0 | 4 | 1 | 6.44 | .333 | 1.43 | 9.3 | 3.7 | 9.3 | 29.1 | 30 | 21 | 21 | 4 | 12 | 30 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 4.17 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 1 | 0 | 1 | 0 | 0.00 | .143 | 0.50 | 4.5 | 0.0 | 4.5 | 4.0 | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.00 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 61 | 12 | 0 | 2 | 2 | 6.87 | .415 | 2.13 | 12.0 | 7.5 | 6.5 | 18.1 | 24 | 14 | 14 | 0 | 15 | 13 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 4.06 |