| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 34 | 34 | 16 | 10 | 3.41 | .304 | 1.29 | 7.4 | 4.3 | 8.7 | 216.2 | 177 | 93 | 82 | 23 | 103 | 208 | 0 | 0 | 0 | 0 | 23 | 4 | 4 | 3.94 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 33 | 33 | 11 | 16 | 4.97 | .317 | 1.38 | 9.3 | 3.1 | 4.4 | 219.0 | 227 | 123 | 121 | 24 | 75 | 107 | 4 | 0 | 0 | 0 | 15 | 3 | 4 | 4.52 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 32 | 32 | 8 | 14 | 4.78 | .324 | 1.41 | 9.4 | 3.3 | 8.2 | 190.1 | 199 | 108 | 101 | 33 | 70 | 173 | 0 | 0 | 0 | 0 | 16 | 5 | 2 | 4.62 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 83 | 32 | 32 | 10 | 14 | 5.37 | .303 | 1.30 | 8.8 | 2.9 | 4.4 | 172.2 | 169 | 107 | 103 | 27 | 55 | 84 | 0 | 0 | 0 | 0 | 10 | 1 | 3 | 5.04 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 68 | 0 | 1 | 11 | 4.33 | .314 | 1.36 | 8.4 | 4.0 | 8.8 | 72.2 | 67 | 35 | 35 | 13 | 32 | 70 | 0 | 40 | 3 | 0 | 0 | 1 | 0 | 4.78 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 72 | 0 | 2 | 5 | 4.46 | .296 | 1.25 | 6.9 | 4.4 | 8.4 | 78.2 | 60 | 39 | 39 | 17 | 38 | 73 | 0 | 3 | 5 | 0 | 0 | 1 | 0 | 5.46 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 80 | 73 | 0 | 5 | 4 | 3.63 | .294 | 1.22 | 6.9 | 4.1 | 8.3 | 74.1 | 57 | 32 | 30 | 8 | 34 | 68 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 4.03 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 48 | 0 | 1 | 1 | 2.98 | .260 | 1.04 | 7.6 | 1.8 | 7.0 | 66.1 | 56 | 24 | 22 | 6 | 13 | 51 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.27 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 37 | 0 | 2 | 1 | 3.29 | .335 | 1.49 | 9.0 | 4.4 | 7.9 | 41.0 | 41 | 15 | 15 | 1 | 20 | 36 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.10 |